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66 results
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Degradation of misfolded proteins prevents ER-derived oxidative stress and cell death.
Haynes CM, Titus EA, Cooper AA. Haynes CM, et al. Mol Cell. 2004 Sep 10;15(5):767-76. doi: 10.1016/j.molcel.2004.08.025. Mol Cell. 2004. PMID: 15350220
An HRD/DER-independent ER quality control mechanism involves Rsp5p-dependent ubiquitination and ER-Golgi transport.
Haynes CM, Caldwell S, Cooper AA. Haynes CM, et al. J Cell Biol. 2002 Jul 8;158(1):91-101. doi: 10.1083/jcb.200201053. Epub 2002 Jul 8. J Cell Biol. 2002. PMID: 12105183 Free PMC article.
Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models.
Cooper AA, Gitler AD, Cashikar A, Haynes CM, Hill KJ, Bhullar B, Liu K, Xu K, Strathearn KE, Liu F, Cao S, Caldwell KA, Caldwell GA, Marsischky G, Kolodner RD, Labaer J, Rochet JC, Bonini NM, Lindquist S. Cooper AA, et al. Among authors: haynes cm. Science. 2006 Jul 21;313(5785):324-8. doi: 10.1126/science.1129462. Epub 2006 Jun 22. Science. 2006. PMID: 16794039 Free PMC article.
An arsenite-inducible 19S regulatory particle-associated protein adapts proteasomes to proteotoxicity.
Stanhill A, Haynes CM, Zhang Y, Min G, Steele MC, Kalinina J, Martinez E, Pickart CM, Kong XP, Ron D. Stanhill A, et al. Among authors: haynes cm. Mol Cell. 2006 Sep 15;23(6):875-85. doi: 10.1016/j.molcel.2006.07.023. Mol Cell. 2006. PMID: 16973439
ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans.
Haynes CM, Petrova K, Benedetti C, Yang Y, Ron D. Haynes CM, et al. Dev Cell. 2007 Oct;13(4):467-80. doi: 10.1016/j.devcel.2007.07.016. Dev Cell. 2007. PMID: 17925224
The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans.
Haynes CM, Yang Y, Blais SP, Neubert TA, Ron D. Haynes CM, et al. Mol Cell. 2010 Feb 26;37(4):529-40. doi: 10.1016/j.molcel.2010.01.015. Mol Cell. 2010. PMID: 20188671 Free PMC article.
Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1.
Wiseman RL, Zhang Y, Lee KP, Harding HP, Haynes CM, Price J, Sicheri F, Ron D. Wiseman RL, et al. Among authors: haynes cm. Mol Cell. 2010 Apr 23;38(2):291-304. doi: 10.1016/j.molcel.2010.04.001. Mol Cell. 2010. PMID: 20417606 Free PMC article.
The mitochondrial UPR - protecting organelle protein homeostasis.
Haynes CM, Ron D. Haynes CM, et al. J Cell Sci. 2010 Nov 15;123(Pt 22):3849-55. doi: 10.1242/jcs.075119. J Cell Sci. 2010. PMID: 21048161 Review.
Mitochondrial protein quality control during biogenesis and aging.
Baker BM, Haynes CM. Baker BM, et al. Among authors: haynes cm. Trends Biochem Sci. 2011 May;36(5):254-61. doi: 10.1016/j.tibs.2011.01.004. Epub 2011 Feb 25. Trends Biochem Sci. 2011. PMID: 21353780 Review.
Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes.
Florey O, Kim SE, Sandoval CP, Haynes CM, Overholtzer M. Florey O, et al. Among authors: haynes cm. Nat Cell Biol. 2011 Oct 16;13(11):1335-43. doi: 10.1038/ncb2363. Nat Cell Biol. 2011. PMID: 22002674 Free PMC article.
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