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Loop-length-dependent folding of G-quadruplexes.
Hazel P, Huppert J, Balasubramanian S, Neidle S. Hazel P, et al. J Am Chem Soc. 2004 Dec 22;126(50):16405-15. doi: 10.1021/ja045154j. J Am Chem Soc. 2004. PMID: 15600342
Quadruplex DNA: sequence, topology and structure.
Burge S, Parkinson GN, Hazel P, Todd AK, Neidle S. Burge S, et al. Among authors: hazel p. Nucleic Acids Res. 2006;34(19):5402-15. doi: 10.1093/nar/gkl655. Epub 2006 Sep 29. Nucleic Acids Res. 2006. PMID: 17012276 Free PMC article. Review.
Predictive modelling of topology and loop variations in dimeric DNA quadruplex structures.
Hazel P, Parkinson GN, Neidle S. Hazel P, et al. Nucleic Acids Res. 2006 Apr 26;34(7):2117-27. doi: 10.1093/nar/gkl182. Print 2006. Nucleic Acids Res. 2006. PMID: 16641317 Free PMC article.
This follows on from our previous MD simulation studies on the influence of loop lengths on the topology of intramolecular quadruplex structures [P. Hazel et al. (2004) J. Am. Chem. Soc., 126, 16 405-16 415], which provided results consistent with biophysical data. …
This follows on from our previous MD simulation studies on the influence of loop lengths on the topology of intramolecular quadruplex struct …
A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration.
Heathcote DA, Patel H, Kroll SH, Hazel P, Periyasamy M, Alikian M, Kanneganti SK, Jogalekar AS, Scheiper B, Barbazanges M, Blum A, Brackow J, Siwicka A, Pace RD, Fuchter MJ, Snyder JP, Liotta DC, Freemont PS, Aboagye EO, Coombes RC, Barrett AG, Ali S. Heathcote DA, et al. Among authors: hazel p. J Med Chem. 2010 Dec 23;53(24):8508-22. doi: 10.1021/jm100732t. Epub 2010 Nov 16. J Med Chem. 2010. PMID: 21080703
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