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Human neutrophils employ the myeloperoxidase-hydrogen peroxide-chloride system to convert hydroxy-amino acids into glycolaldehyde, 2-hydroxypropanal, and acrolein. A mechanism for the generation of highly reactive alpha-hydroxy and alpha,beta-unsaturated aldehydes by phagocytes at sites of inflammation.
Anderson MM, Hazen SL, Hsu FF, Heinecke JW. Anderson MM, et al. Among authors: hazen sl. J Clin Invest. 1997 Feb 1;99(3):424-32. doi: 10.1172/JCI119176. J Clin Invest. 1997. PMID: 9022075 Free PMC article.
484 results