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3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima.
Hazen SL, Heinecke JW. Hazen SL, et al. J Clin Invest. 1997 May 1;99(9):2075-81. doi: 10.1172/JCI119379. J Clin Invest. 1997. PMID: 9151778 Free PMC article.
Human neutrophils employ the myeloperoxidase-hydrogen peroxide-chloride system to convert hydroxy-amino acids into glycolaldehyde, 2-hydroxypropanal, and acrolein. A mechanism for the generation of highly reactive alpha-hydroxy and alpha,beta-unsaturated aldehydes by phagocytes at sites of inflammation.
Anderson MM, Hazen SL, Hsu FF, Heinecke JW. Anderson MM, et al. Among authors: hazen sl. J Clin Invest. 1997 Feb 1;99(3):424-32. doi: 10.1172/JCI119176. J Clin Invest. 1997. PMID: 9022075 Free PMC article.
Human neutrophils employ chlorine gas as an oxidant during phagocytosis.
Hazen SL, Hsu FF, Mueller DM, Crowley JR, Heinecke JW. Hazen SL, et al. J Clin Invest. 1996 Sep 15;98(6):1283-9. doi: 10.1172/JCI118914. J Clin Invest. 1996. PMID: 8823292 Free PMC article.
p-Hydroxyphenylacetaldehyde is the major product of L-tyrosine oxidation by activated human phagocytes. A chloride-dependent mechanism for the conversion of free amino acids into reactive aldehydes by myeloperoxidase.
Hazen SL, Hsu FF, Heinecke JW. Hazen SL, et al. J Biol Chem. 1996 Jan 26;271(4):1861-7. doi: 10.1074/jbc.271.4.1861. J Biol Chem. 1996. PMID: 8567631
Isolation of a human myocardial cytosolic phospholipase A2 isoform. Fast atom bombardment mass spectroscopic and reverse-phase high pressure liquid chromatography identification of choline and ethanolamine glycerophospholipid substrates.
Hazen SL, Hall CR, Ford DA, Gross RW. Hazen SL, et al. J Clin Invest. 1993 Jun;91(6):2513-22. doi: 10.1172/JCI116487. J Clin Invest. 1993. PMID: 8514863 Free PMC article.
The rapid and reversible activation of a calcium-independent plasmalogen-selective phospholipase A2 during myocardial ischemia.
Ford DA, Hazen SL, Saffitz JE, Gross RW. Ford DA, et al. Among authors: hazen sl. J Clin Invest. 1991 Jul;88(1):331-5. doi: 10.1172/JCI115296. J Clin Invest. 1991. PMID: 2056126 Free PMC article.
Chem. 260:7295-7303; and Hazen, S. L., D. A. Ford, and R. W. Gross. 1991. J. Biol. Chem. 266:5629-5633). To examine the potential role of these calcium-independent phospholipases A2 in mediating membrane dysfunction during early myocardial ischemia, the temporal course of …
Chem. 260:7295-7303; and Hazen, S. L., D. A. Ford, and R. W. Gross. 1991. J. Biol. Chem. 266:5629-5633). To examine the potential rol …
Human myocardial cytosolic Ca(2+)-independent phospholipase A2 is modulated by ATP. Concordant ATP-induced alterations in enzyme kinetics and mechanism-based inhibition.
Hazen SL, Gross RW. Hazen SL, et al. Biochem J. 1991 Dec 15;280 ( Pt 3)(Pt 3):581-7. doi: 10.1042/bj2800581. Biochem J. 1991. PMID: 1764021 Free PMC article.
Synthesis, isolation, and characterization of the adduct formed in the reaction of p-hydroxyphenylacetaldehyde with the amino headgroup of phosphatidylethanolamine and phosphatidylserine.
Hazen SL, Heller J, Hsu FF, d'Avignon A, Heinecke JW. Hazen SL, et al. Chem Res Toxicol. 1999 Jan;12(1):19-27. doi: 10.1021/tx980147s. Chem Res Toxicol. 1999. PMID: 9894014
Human neutrophils employ myeloperoxidase to convert alpha-amino acids to a battery of reactive aldehydes: a pathway for aldehyde generation at sites of inflammation.
Hazen SL, Hsu FF, d'Avignon A, Heinecke JW. Hazen SL, et al. Biochemistry. 1998 May 12;37(19):6864-73. doi: 10.1021/bi972449j. Biochemistry. 1998. PMID: 9578573
Human neutrophils employ the myeloperoxidase-hydrogen peroxide-chloride system to oxidize alpha-amino acids to a family of reactive aldehydes. Mechanistic studies identifying labile intermediates along the reaction pathway.
Hazen SL, d'Avignon A, Anderson MM, Hsu FF, Heinecke JW. Hazen SL, et al. J Biol Chem. 1998 Feb 27;273(9):4997-5005. doi: 10.1074/jbc.273.9.4997. J Biol Chem. 1998. PMID: 9478947
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