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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1963 3
1964 7
1965 1
1966 5
1967 6
1968 7
1969 11
1970 6
1971 13
1972 24
1973 21
1974 34
1975 16
1976 18
1977 13
1978 5
1979 13
1980 25
1981 22
1982 20
1983 30
1984 26
1985 35
1986 22
1987 26
1988 25
1989 55
1990 50
1991 57
1992 40
1993 55
1994 43
1995 36
1996 73
1997 46
1998 57
1999 53
2000 58
2001 100
2002 69
2003 89
2004 93
2005 87
2006 73
2007 95
2008 100
2009 94
2010 88
2011 119
2012 113
2013 126
2014 131
2015 142
2016 153
2017 151
2018 139
2019 139
2020 139
2021 131
2022 129
2023 116
2024 36

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3,451 results

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Page 1
Advances in the diagnosis and treatment of sickle cell disease.
Brandow AM, Liem RI. Brandow AM, et al. J Hematol Oncol. 2022 Mar 3;15(1):20. doi: 10.1186/s13045-022-01237-z. J Hematol Oncol. 2022. PMID: 35241123 Free PMC article. Review.
Sickle cell disease (SCD), which affects approximately 100,000 individuals in the USA and more than 3 million worldwide, is caused by mutations in the betab globin gene that result in sickle hemoglobin production. Sickle hemoglobin polymerizatio
Sickle cell disease (SCD), which affects approximately 100,000 individuals in the USA and more than 3 million worldwide
Sickle cell disease: A primary care update.
Onimoe G, Rotz S. Onimoe G, et al. Cleve Clin J Med. 2020 Jan;87(1):19-27. doi: 10.3949/ccjm.87a.18051. Epub 2020 Jan 2. Cleve Clin J Med. 2020. PMID: 31990651 Free article. Review.
Sickle cell disease (SCD) is the most common hemoglobinopathy in the United States and causes significant disease-related morbidity including multiorgan damage, chronic anemia, and debilitating pain crises. ...This review focuses on current reco
Sickle cell disease (SCD) is the most common hemoglobinopathy in the United States and causes significant disease
Pathophysiology of Sickle Cell Disease.
Sundd P, Gladwin MT, Novelli EM. Sundd P, et al. Annu Rev Pathol. 2019 Jan 24;14:263-292. doi: 10.1146/annurev-pathmechdis-012418-012838. Epub 2018 Oct 17. Annu Rev Pathol. 2019. PMID: 30332562 Free PMC article. Review.
Since the discovery of sickle cell disease (SCD) in 1910, enormous strides have been made in the elucidation of the pathogenesis of its protean complications, which has inspired recent advances in targeted molecular therapies. ...Clinically, erythrocyte abnor …
Since the discovery of sickle cell disease (SCD) in 1910, enormous strides have been made in the elucidation of the pat …
Sickle Cell Anemia and Its Phenotypes.
Williams TN, Thein SL. Williams TN, et al. Annu Rev Genomics Hum Genet. 2018 Aug 31;19:113-147. doi: 10.1146/annurev-genom-083117-021320. Epub 2018 Apr 11. Annu Rev Genomics Hum Genet. 2018. PMID: 29641911 Free PMC article. Review.
In the 100 years since sickle cell anemia (SCA) was first described in the medical literature, studies of its molecular and pathophysiological basis have been at the vanguard of scientific discovery. ...Meanwhile, an unprecedented number of new drugs aimed at …
In the 100 years since sickle cell anemia (SCA) was first described in the medical literature, studies of its molecular …
Neurologic Complications of Sickle Cell Disease.
Farooq S, Testai FD. Farooq S, et al. Curr Neurol Neurosci Rep. 2019 Feb 28;19(4):17. doi: 10.1007/s11910-019-0932-0. Curr Neurol Neurosci Rep. 2019. PMID: 30820687 Review.
PURPOSE OF REVIEW: Sickle cell anemia is a multiorgan disease with acute and chronic complications. ...Treatment varies depending on the neurological complication. Sickle cell disease is the most common hereditary anemia wit …
PURPOSE OF REVIEW: Sickle cell anemia is a multiorgan disease with acute and chronic complications. ...Treatment …
Sickle Cell Disease.
Piel FB, Steinberg MH, Rees DC. Piel FB, et al. N Engl J Med. 2017 Apr 20;376(16):1561-1573. doi: 10.1056/NEJMra1510865. N Engl J Med. 2017. PMID: 28423290 Free article. Review. No abstract available.
Sickle cell disease: a review for the internist.
Pinto VM, Balocco M, Quintino S, Forni GL. Pinto VM, et al. Intern Emerg Med. 2019 Oct;14(7):1051-1064. doi: 10.1007/s11739-019-02160-x. Epub 2019 Aug 5. Intern Emerg Med. 2019. PMID: 31385153 Review.
Sickle cell disease (SCD) is the most important hemoglobinopathy worldwide in terms of frequency and social impact, recently recognized as a global public health problem by the World Health Organization. It is a monogenic but multisystem disorder with high mo
Sickle cell disease (SCD) is the most important hemoglobinopathy worldwide in terms of frequency and social impact, rec
Treatment Options for Sickle Cell Disease.
Meier ER. Meier ER. Pediatr Clin North Am. 2018 Jun;65(3):427-443. doi: 10.1016/j.pcl.2018.01.005. Pediatr Clin North Am. 2018. PMID: 29803275 Review.
Sickle cell disease (SCD) complications begin with the polymerization of sickle hemoglobin (HbS). ...This article focuses on supportive and preventive care improvements and the benefits of hydroxyurea. Indications for erythrocyte transfusion, hematopoi
Sickle cell disease (SCD) complications begin with the polymerization of sickle hemoglobin (HbS). ...This articl
Sickle cell trait diagnosis: clinical and social implications.
Naik RP, Haywood C Jr. Naik RP, et al. Hematology Am Soc Hematol Educ Program. 2015;2015(1):160-7. doi: 10.1182/asheducation-2015.1.160. Hematology Am Soc Hematol Educ Program. 2015. PMID: 26637716 Free PMC article. Review.
The sickle hemoglobin (HbS) point mutation has independently undergone evolutionary selection at least five times in the world because of its overwhelming malarial protective effects in the heterozygous state. In 1949, homozygous Hb S or sickle cell
The sickle hemoglobin (HbS) point mutation has independently undergone evolutionary selection at least five times in the world becaus …
Sickle Cell Disease: Monitoring, Current Treatment, and Therapeutics Under Development.
Hoppe C, Neumayr L. Hoppe C, et al. Hematol Oncol Clin North Am. 2019 Jun;33(3):355-371. doi: 10.1016/j.hoc.2019.01.014. Epub 2019 Mar 28. Hematol Oncol Clin North Am. 2019. PMID: 31030807 Review.
Screening and early detection of organ injury, as well as expanded use of red cell transfusion and hydroxyurea in children have changed best practices for clinical care in sickle cell disease. The current standard of care for children with sickle
Screening and early detection of organ injury, as well as expanded use of red cell transfusion and hydroxyurea in children have chang …
3,451 results