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9,288 results
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P21-activated kinase 1 stimulates colon cancer cell growth and migration/invasion via ERK- and AKT-dependent pathways.
Huynh N, Liu KH, Baldwin GS, He H. Huynh N, et al. Among authors: he h. Biochim Biophys Acta. 2010 Sep;1803(9):1106-13. doi: 10.1016/j.bbamcr.2010.05.007. Epub 2010 Jun 1. Biochim Biophys Acta. 2010. PMID: 20595063
G proteins, phosphoinositides, and actin-cytoskeleton in the control of cancer growth.
Maruta H, He H, Tikoo A, Vuong T, Nur-E-Kamal M. Maruta H, et al. Among authors: he h. Microsc Res Tech. 1999 Oct 1;47(1):61-6. doi: 10.1002/(SICI)1097-0029(19991001)47:1<61::AID-JEMT6>3.0.CO;2-Y. Microsc Res Tech. 1999. PMID: 10506762 Review.
Cytoskeletal tumor suppressors that block oncogenic RAS signaling.
Maruta H, He H, Tikoo A, Nur-e-Kamal M. Maruta H, et al. Among authors: he h. Ann N Y Acad Sci. 1999;886:48-57. doi: 10.1111/j.1749-6632.1999.tb09399.x. Ann N Y Acad Sci. 1999. PMID: 10667202 Review.
An anti-Ras cancer potential of PP1, an inhibitor specific for Src family kinases: in vitro and in vivo studies.
He H, Hirokawa Y, Levitzki A, Maruta H. He H, et al. Cancer J. 2000 Jul-Aug;6(4):243-8. Cancer J. 2000. PMID: 11038144
Platelet-derived growth factor requires epidermal growth factor receptor to activate p21-activated kinase family kinases.
He H, Levitzki A, Zhu HJ, Walker F, Burgess A, Maruta H. He H, et al. J Biol Chem. 2001 Jul 20;276(29):26741-4. doi: 10.1074/jbc.C100229200. Epub 2001 May 16. J Biol Chem. 2001. PMID: 11356824
Signal therapy for RAS-induced cancers in combination of AG 879 and PP1, specific inhibitors for ErbB2 and Src family kinases, that block PAK activation.
He H, Hirokawa Y, Manser E, Lim L, Levitzki A, Maruta H. He H, et al. Cancer J. 2001 May-Jun;7(3):191-202. Cancer J. 2001. PMID: 11419027
The K252a derivatives, inhibitors for the PAK/MLK kinase family selectively block the growth of RAS transformants.
Nheu TV, He H, Hirokawa Y, Tamaki K, Florin L, Schmitz ML, Suzuki-Takahashi I, Jorissen RN, Burgess AW, Nishimura S, Wood J, Maruta H. Nheu TV, et al. Among authors: he h. Cancer J. 2002 Jul-Aug;8(4):328-36. doi: 10.1097/00130404-200207000-00009. Cancer J. 2002. PMID: 12184411
Rho family-associated kinases PAK1 and rock.
Maruta H, Nheu TV, He H, Hirokawa Y. Maruta H, et al. Among authors: he h. Prog Cell Cycle Res. 2003;5:203-10. Prog Cell Cycle Res. 2003. PMID: 14593714 Review.
PAK is essential for RAS-induced upregulation of cyclin D1 during the G1 to S transition.
Nheu T, He H, Hirokawa Y, Walker F, Wood J, Maruta H. Nheu T, et al. Among authors: he h. Cell Cycle. 2004 Jan;3(1):71-4. Cell Cycle. 2004. PMID: 14657670
The Tyr-kinase inhibitor AG879, that blocks the ETK-PAK1 interaction, suppresses the RAS-induced PAK1 activation and malignant transformation.
He H, Hirokawa Y, Gazit A, Yamashita Y, Mano H, Kawakami Y, Kawakami, Hsieh CY, Kung HJ, Lessene G, Baell J, Levitzki A, Maruta H. He H, et al. Cancer Biol Ther. 2004 Jan;3(1):96-101. doi: 10.4161/cbt.3.1.643. Epub 2004 Jan 29. Cancer Biol Ther. 2004. PMID: 14726663
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