He YA - Search Results

1

Site-directed mutagenesis as a tool for molecular modeling of cytochrome P450 2B1.

Szklarz GD, He YA, Halpert JR. Szklarz GD, et al. Among authors: he ya. Biochemistry. 1995 Nov 7;34(44):14312-22. doi: 10.1021/bi00044a008. Biochemistry. 1995. PMID: 7578035

2

Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding.

Scott EE, White MA, He YA, Johnson EF, Stout CD, Halpert JR. Scott EE, et al. Among authors: he ya. J Biol Chem. 2004 Jun 25;279(26):27294-301. doi: 10.1074/jbc.M403349200. Epub 2004 Apr 20. J Biol Chem. 2004. PMID: 15100217

3

Topological changes in the CYP3A4 active site probed with phenyldiazene: effect of interaction with NADPH-cytochrome P450 reductase and cytochrome b5 and of site-directed mutagenesis.

Yamaguchi Y, Khan KK, He YA, He YQ, Halpert JR. Yamaguchi Y, et al. Among authors: he ya, he yq. Drug Metab Dispos. 2004 Jan;32(1):155-61. doi: 10.1124/dmd.32.1.155. Drug Metab Dispos. 2004. PMID: 14709633

4

An open conformation of mammalian cytochrome P450 2B4 at 1.6-A resolution.

Scott EE, He YA, Wester MR, White MA, Chin CC, Halpert JR, Johnson EF, Stout CD. Scott EE, et al. Among authors: he ya. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13196-201. doi: 10.1073/pnas.2133986100. Epub 2003 Oct 16. Proc Natl Acad Sci U S A. 2003. PMID: 14563924 Free PMC article.

5

Site-directed mutagenesis of cytochrome P450eryF: implications for substrate oxidation, cooperativity, and topology of the active site.

Khan KK, He YA, He YQ, Halpert JR. Khan KK, et al. Among authors: he ya, he yq. Chem Res Toxicol. 2002 Jun;15(6):843-53. doi: 10.1021/tx025539k. Chem Res Toxicol. 2002. PMID: 12067252

6

Analysis of homotropic and heterotropic cooperativity of diazepam oxidation by CYP3A4 using site-directed mutagenesis and kinetic modeling.

He YA, Roussel F, Halpert JR. He YA, et al. Arch Biochem Biophys. 2003 Jan 1;409(1):92-101. doi: 10.1016/s0003-9861(02)00484-8. Arch Biochem Biophys. 2003. PMID: 12464248

7

CYP3A4 is a vitamin D-24- and 25-hydroxylase: analysis of structure function by site-directed mutagenesis.

Gupta RP, He YA, Patrick KS, Halpert JR, Bell NH. Gupta RP, et al. Among authors: he ya. J Clin Endocrinol Metab. 2005 Feb;90(2):1210-9. doi: 10.1210/jc.2004-0966. Epub 2004 Nov 16. J Clin Endocrinol Metab. 2005. PMID: 15546903

8

Activation of the anticancer prodrugs cyclophosphamide and ifosfamide: identification of cytochrome P450 2B enzymes and site-specific mutants with improved enzyme kinetics.

Chen CS, Lin JT, Goss KA, He YA, Halpert JR, Waxman DJ. Chen CS, et al. Among authors: he ya. Mol Pharmacol. 2004 May;65(5):1278-85. doi: 10.1124/mol.65.5.1278. Mol Pharmacol. 2004. PMID: 15102956

9

2,2',3,3',6,6'-hexachlorobiphenyl hydroxylation by active site mutants of cytochrome P450 2B1 and 2B11.

Waller SC, He YA, Harlow GR, He YQ, Mash EA, Halpert JR. Waller SC, et al. Among authors: he ya, he yq. Chem Res Toxicol. 1999 Aug;12(8):690-9. doi: 10.1021/tx990030j. Chem Res Toxicol. 1999. PMID: 10458702

10

Identification of three key residues in substrate recognition site 5 of human cytochrome P450 3A4 by cassette and site-directed mutagenesis.

He YA, He YQ, Szklarz GD, Halpert JR. He YA, et al. Among authors: he yq. Biochemistry. 1997 Jul 22;36(29):8831-9. doi: 10.1021/bi970182i. Biochemistry. 1997. PMID: 9220969

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