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Preclinical validation of a potent γ-secretase modulator for Alzheimer's disease prevention.
Rynearson KD, Ponnusamy M, Prikhodko O, Xie Y, Zhang C, Nguyen P, Hug B, Sawa M, Becker A, Spencer B, Florio J, Mante M, Salehi B, Arias C, Galasko D, Head BP, Johnson G, Lin JH, Duddy SK, Rissman RA, Mobley WC, Thinakaran G, Tanzi RE, Wagner SL. Rynearson KD, et al. Among authors: head bp. J Exp Med. 2021 Apr 5;218(4):e20202560. doi: 10.1084/jem.20202560. J Exp Med. 2021. PMID: 33651103 Free PMC article.
Inhibition of RhoA reduces propofol-mediated growth cone collapse, axonal transport impairment, loss of synaptic connectivity, and behavioural deficits.
Pearn ML, Schilling JM, Jian M, Egawa J, Wu C, Mandyam CD, Fannon-Pavlich MJ, Nguyen U, Bertoglio J, Kodama M, Mahata SK, DerMardirossian C, Lemkuil BP, Han R, Mobley WC, Patel HH, Patel PM, Head BP. Pearn ML, et al. Among authors: head bp. Br J Anaesth. 2018 Apr;120(4):745-760. doi: 10.1016/j.bja.2017.12.033. Epub 2018 Feb 15. Br J Anaesth. 2018. PMID: 29576115 Free PMC article.
Mitochondria-localized caveolin in adaptation to cellular stress and injury.
Fridolfsson HN, Kawaraguchi Y, Ali SS, Panneerselvam M, Niesman IR, Finley JC, Kellerhals SE, Migita MY, Okada H, Moreno AL, Jennings M, Kidd MW, Bonds JA, Balijepalli RC, Ross RS, Patel PM, Miyanohara A, Chen Q, Lesnefsky EJ, Head BP, Roth DM, Insel PA, Patel HH. Fridolfsson HN, et al. Among authors: head bp. FASEB J. 2012 Nov;26(11):4637-49. doi: 10.1096/fj.12-215798. Epub 2012 Aug 2. FASEB J. 2012. PMID: 22859372 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 35557108
Synapsin-caveolin-1 gene therapy preserves neuronal and synaptic morphology and prevents neurodegeneration in a mouse model of AD.
Wang S, Leem JS, Podvin S, Hook V, Kleschevnikov N, Savchenko P, Dhanani M, Zhou K, Kelly IC, Zhang T, Miyanohara A, Nguyen P, Kleschevnikov A, Wagner SL, Trojanowski JQ, Roth DM, Patel HH, Patel PM, Head BP. Wang S, et al. Among authors: head bp. Mol Ther Methods Clin Dev. 2021 Mar 29;21:434-450. doi: 10.1016/j.omtm.2021.03.021. eCollection 2021 Jun 11. Mol Ther Methods Clin Dev. 2021. PMID: 33981778 Free PMC article.
Amyloidogenic Processing of Amyloid Precursor Protein Drives Stretch-Induced Disruption of Axonal Transport in hiPSC-Derived Neurons.
Chaves RS, Tran M, Holder AR, Balcer AM, Dickey AM, Roberts EA, Bober BG, Gutierrez E, Head BP, Groisman A, Goldstein LSB, Almenar-Queralt A, Shah SB. Chaves RS, et al. Among authors: head bp. J Neurosci. 2021 Dec 8;41(49):10034-10053. doi: 10.1523/JNEUROSCI.2553-20.2021. Epub 2021 Oct 18. J Neurosci. 2021. PMID: 34663629 Free PMC article.
94 results