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Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines.
Hecht SS. Hecht SS. Chem Res Toxicol. 1998 Jun;11(6):559-603. doi: 10.1021/tx980005y. Chem Res Toxicol. 1998. PMID: 9625726 Review. No abstract available.
Enantiomeric composition of N'-nitrosonornicotine and N'-nitrosoanatabine in tobacco.
Carmella SG, McIntee EJ, Chen M, Hecht SS. Carmella SG, et al. Among authors: hecht ss. Carcinogenesis. 2000 Apr;21(4):839-43. doi: 10.1093/carcin/21.4.839. Carcinogenesis. 2000. PMID: 10753225
Formation and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol enantiomers in vitro in mouse, rat and human tissues.
Upadhyaya P, Carmella SG, Guengerich FP, Hecht SS. Upadhyaya P, et al. Among authors: hecht ss. Carcinogenesis. 2000 Jun;21(6):1233-8. Carcinogenesis. 2000. PMID: 10837015
Stereoselective metabolism of nicotine and tobacco-specific N-nitrosamines to 4-hydroxy-4-(3-pyridyl)butanoic acid in rats.
Trushin N, Hecht SS. Trushin N, et al. Among authors: hecht ss. Chem Res Toxicol. 1999 Feb;12(2):164-71. doi: 10.1021/tx980213q. Chem Res Toxicol. 1999. PMID: 10027794
Approaches to the development of assays for interaction of tobacco-specific nitrosamines with haemoglobin and DNA.
Hecht SS, Carmella SG, Trushin N, Spratt TE, Foiles PG, Hoffmann D. Hecht SS, et al. IARC Sci Publ. 1988;(89):121-8. IARC Sci Publ. 1988. PMID: 3198194
Evaluation of the transplacental tumorigenicity of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice.
Anderson LM, Hecht SS, Dixon DE, Dove LF, Kovatch RM, Amin S, Hoffmann D, Rice JM. Anderson LM, et al. Among authors: hecht ss. Cancer Res. 1989 Jul 15;49(14):3770-5. Cancer Res. 1989. PMID: 2736518
Solvolysis of model compounds for alpha-hydroxylation of N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: evidence for a cyclic oxonium ion intermediate in the alkylation of nucleophiles.
Spratt TE, Peterson LA, Confer WL, Hecht SS. Spratt TE, et al. Among authors: hecht ss. Chem Res Toxicol. 1990 Jul-Aug;3(4):350-6. doi: 10.1021/tx00016a013. Chem Res Toxicol. 1990. PMID: 2133084
Pyridyloxobutyl adduct O6-[4-oxo-4-(3-pyridyl)butyl]guanine is present in 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone-treated DNA and is a substrate for O6-alkylguanine-DNA alkyltransferase.
Wang L, Spratt TE, Liu XK, Hecht SS, Pegg AE, Peterson LA. Wang L, et al. Among authors: hecht ss. Chem Res Toxicol. 1997 May;10(5):562-7. doi: 10.1021/tx9602067. Chem Res Toxicol. 1997. PMID: 9168254
The biological significance of tobacco-specific N-nitrosamines: smoking and adenocarcinoma of the lung.
Hoffmann D, Rivenson A, Hecht SS. Hoffmann D, et al. Among authors: hecht ss. Crit Rev Toxicol. 1996;26(2):199-211. doi: 10.3109/10408449609017931. Crit Rev Toxicol. 1996. PMID: 8688161 Review.
Carcinogenicity of tobacco-specific N-nitrosamines (TSNA): the role of the vascular network in the selection of target organs.
Rivenson A, Hecht SS, Hoffmann D. Rivenson A, et al. Among authors: hecht ss. Crit Rev Toxicol. 1991;21(4):255-64. doi: 10.3109/10408449109017913. Crit Rev Toxicol. 1991. PMID: 2069711 Review. No abstract available.
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