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Crystal structure of glucokinase regulatory protein.
Pautsch A, Stadler N, Löhle A, Rist W, Berg A, Glocker L, Nar H, Reinert D, Lenter M, Heckel A, Schnapp G, Kauschke SG. Pautsch A, et al. Among authors: heckel a. Biochemistry. 2013 May 21;52(20):3523-31. doi: 10.1021/bi4000782. Epub 2013 May 9. Biochemistry. 2013. PMID: 23621087
Design, synthesis and evaluation of MCH receptor 1 antagonists--Part I: Optimization of HTS hits towards an in vivo efficacious tool compound BI 414.
Müller SG, Heckel A, Kley JT, Lehmann T, Lustenberger P, Oost T, Roth GJ, Rudolf K, Arndt K, Lenter M, Lotz RR, Maier GM, Markert M, Schindler M, Stenkamp D. Müller SG, et al. Among authors: heckel a. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3264-9. doi: 10.1016/j.bmcl.2015.05.077. Epub 2015 Jun 6. Bioorg Med Chem Lett. 2015. PMID: 26112443
Design, synthesis and evaluation of MCH receptor 1 antagonists--Part III: Discovery of pre-clinical development candidate BI 186908.
Oost T, Heckel A, Kley JT, Lehmann T, Müller S, Roth GJ, Rudolf K, Arndt K, Budzinski R, Lenter M, Lotz RR, Maier GM, Markert M, Thomas L, Stenkamp D. Oost T, et al. Among authors: heckel a. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3275-80. doi: 10.1016/j.bmcl.2015.05.065. Epub 2015 May 29. Bioorg Med Chem Lett. 2015. PMID: 26105194
Phenocopy--a strategy to qualify chemical compounds during hit-to-lead and/or lead optimization.
Baum P, Schmid R, Ittrich C, Rust W, Fundel-Clemens K, Siewert S, Baur M, Mara L, Gruenbaum L, Heckel A, Eils R, Kontermann RE, Roth GJ, Gantner F, Schnapp A, Park JE, Weith A, Quast K, Mennerich D. Baum P, et al. Among authors: heckel a. PLoS One. 2010 Dec 10;5(12):e14272. doi: 10.1371/journal.pone.0014272. PLoS One. 2010. PMID: 21170314 Free PMC article.
Design, synthesis and evaluation of MCH receptor 1 antagonists--Part II: Optimization of pyridazines toward reduced phospholipidosis and hERG inhibition.
Roth GJ, Heckel A, Kley JT, Lehmann T, Müller SG, Oost T, Rudolf K, Arndt K, Budzinski R, Lenter M, Lotz RR, Schindler M, Thomas L, Stenkamp D. Roth GJ, et al. Among authors: heckel a. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3270-4. doi: 10.1016/j.bmcl.2015.05.074. Epub 2015 May 30. Bioorg Med Chem Lett. 2015. PMID: 26077492
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