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Patient-derived Models of Abiraterone- and Enzalutamide-resistant Prostate Cancer Reveal Sensitivity to Ribosome-directed Therapy.
Lawrence MG, Obinata D, Sandhu S, Selth LA, Wong SQ, Porter LH, Lister N, Pook D, Pezaro CJ, Goode DL, Rebello RJ, Clark AK, Papargiris M, Van Gramberg J, Hanson AR, Banks P, Wang H, Niranjan B, Keerthikumar S, Hedwards S, Huglo A, Yang R, Henzler C, Li Y, Lopez-Campos F, Castro E, Toivanen R, Azad A, Bolton D, Goad J, Grummet J, Harewood L, Kourambas J, Lawrentschuk N, Moon D, Murphy DG, Sengupta S, Snow R, Thorne H, Mitchell C, Pedersen J, Clouston D, Norden S, Ryan A, Dehm SM, Tilley WD, Pearson RB, Hannan RD, Frydenberg M, Furic L, Taylor RA, Risbridger GP. Lawrence MG, et al. Among authors: hedwards s. Eur Urol. 2018 Nov;74(5):562-572. doi: 10.1016/j.eururo.2018.06.020. Epub 2018 Jul 23. Eur Urol. 2018. PMID: 30049486 Free PMC article.
Early-onset endocrine disruptor-induced prostatitis in the rat.
Cowin PA, Foster P, Pedersen J, Hedwards S, McPherson SJ, Risbridger GP. Cowin PA, et al. Among authors: hedwards s. Environ Health Perspect. 2008 Jul;116(7):923-9. doi: 10.1289/ehp.11239. Environ Health Perspect. 2008. PMID: 18629315 Free PMC article.
Activin C antagonizes activin A in vitro and overexpression leads to pathologies in vivo.
Gold E, Jetly N, O'Bryan MK, Meachem S, Srinivasan D, Behuria S, Sanchez-Partida LG, Woodruff T, Hedwards S, Wang H, McDougall H, Casey V, Niranjan B, Patella S, Risbridger G. Gold E, et al. Among authors: hedwards s. Am J Pathol. 2009 Jan;174(1):184-95. doi: 10.2353/ajpath.2009.080296. Epub 2008 Dec 18. Am J Pathol. 2009. PMID: 19095948 Free PMC article.
Estrogen receptor-beta activated apoptosis in benign hyperplasia and cancer of the prostate is androgen independent and TNFalpha mediated.
McPherson SJ, Hussain S, Balanathan P, Hedwards SL, Niranjan B, Grant M, Chandrasiri UP, Toivanen R, Wang Y, Taylor RA, Risbridger GP. McPherson SJ, et al. Among authors: hedwards sl. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3123-8. doi: 10.1073/pnas.0905524107. Epub 2010 Feb 1. Proc Natl Acad Sci U S A. 2010. PMID: 20133657 Free PMC article.