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416 results
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Targeting the proper amyloid-beta neuronal toxins: a path forward for Alzheimer's disease immunotherapeutics.
Goure WF, Krafft GA, Jerecic J, Hefti F. Goure WF, et al. Among authors: hefti f. Alzheimers Res Ther. 2014 Jul 9;6(4):42. doi: 10.1186/alzrt272. eCollection 2014. Alzheimers Res Ther. 2014. PMID: 25045405 Free PMC article. Review.
Conformation as the Therapeutic Target for Neurodegenerative Diseases.
Krishnan R, Hefti F, Tsubery H, Lulu M, Proschitsky M, Fisher R. Krishnan R, et al. Among authors: hefti f. Curr Alzheimer Res. 2017;14(4):393-402. doi: 10.2174/1567205014666170116152622. Curr Alzheimer Res. 2017. PMID: 28093972 Review.
An acute functional screen identifies an effective antibody targeting amyloid-β oligomers based on calcium imaging.
Wang X, Kastanenka KV, Arbel-Ornath M, Commins C, Kuzuya A, Lariviere AJ, Krafft GA, Hefti F, Jerecic J, Bacskai BJ. Wang X, et al. Among authors: hefti f. Sci Rep. 2018 Mar 15;8(1):4634. doi: 10.1038/s41598-018-22979-2. Sci Rep. 2018. PMID: 29545579 Free PMC article.
The case for soluble Aβ oligomers as a drug target in Alzheimer's disease.
Hefti F, Goure WF, Jerecic J, Iverson KS, Walicke PA, Krafft GA. Hefti F, et al. Trends Pharmacol Sci. 2013 May;34(5):261-6. doi: 10.1016/ Epub 2013 Apr 10. Trends Pharmacol Sci. 2013. PMID: 23582316
Correlation of amyloid PET ligand florbetapir F 18 binding with Aβ aggregation and neuritic plaque deposition in postmortem brain tissue.
Choi SR, Schneider JA, Bennett DA, Beach TG, Bedell BJ, Zehntner SP, Krautkramer MJ, Kung HF, Skovronsky DM, Hefti F, Clark CM. Choi SR, et al. Among authors: hefti f. Alzheimer Dis Assoc Disord. 2012 Jan-Mar;26(1):8-16. doi: 10.1097/WAD.0b013e31821300bc. Alzheimer Dis Assoc Disord. 2012. PMID: 22354138 Free PMC article.
Novel class of pain drugs based on antagonism of NGF.
Hefti FF, Rosenthal A, Walicke PA, Wyatt S, Vergara G, Shelton DL, Davies AM. Hefti FF, et al. Trends Pharmacol Sci. 2006 Feb;27(2):85-91. doi: 10.1016/ Epub 2005 Dec 27. Trends Pharmacol Sci. 2006. PMID: 16376998 Review.
Development of effective therapy for Alzheimer's disease based on neurotrophic factors.
Hefti F. Hefti F. Neurobiol Aging. 1994;15 Suppl 2:S193-4. doi: 10.1016/0197-4580(94)90204-6. Neurobiol Aging. 1994. PMID: 7700452 Review.
Nerve growth factor and Alzheimer's disease.
Hefti F, Schneider LS. Hefti F, et al. Clin Neuropharmacol. 1991;14 Suppl 1:S62-76. doi: 10.1097/00002826-199114001-00008. Clin Neuropharmacol. 1991. PMID: 1913710 Review.
Development of neurotrophic factor therapy for Alzheimer's disease.
Hefti F, Armanini MP, Beck KD, Caras IW, Chen KS, Godowski PJ, Goodman LJ, Hammonds RG, Mark MR, Moran P, Nishimura MC, Phillips HS, Shih A, Valverde J, Winslow JW. Hefti F, et al. Ciba Found Symp. 1996;196:54-63; discussion 63-9. doi: 10.1002/9780470514863.ch5. Ciba Found Symp. 1996. PMID: 8991782 Review. No abstract available.
Nerve growth factor and Alzheimer's disease.
Hefti F, Weiner WJ. Hefti F, et al. Ann Neurol. 1986 Sep;20(3):275-81. doi: 10.1002/ana.410200302. Ann Neurol. 1986. PMID: 3532929 Review.
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