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An antibody that locks HER3 in the inactive conformation inhibits tumor growth driven by HER2 or neuregulin.
Garner AP, Bialucha CU, Sprague ER, Garrett JT, Sheng Q, Li S, Sineshchekova O, Saxena P, Sutton CR, Chen D, Chen Y, Wang H, Liang J, Das R, Mosher R, Gu J, Huang A, Haubst N, Zehetmeier C, Haberl M, Elis W, Kunz C, Heidt AB, Herlihy K, Murtie J, Schuller A, Arteaga CL, Sellers WR, Ettenberg SA. Garner AP, et al. Among authors: heidt ab. Cancer Res. 2013 Oct 1;73(19):6024-35. doi: 10.1158/0008-5472.CAN-13-1198. Epub 2013 Aug 8. Cancer Res. 2013. PMID: 23928993 Free PMC article.
Small molecules not direct activators of caspases.
Denault JB, Drag M, Salvesen GS, Alves J, Heidt AB, Deveraux Q, Harris JL. Denault JB, et al. Among authors: heidt ab. Nat Chem Biol. 2007 Sep;3(9):519; author reply 520. doi: 10.1038/nchembio0907-519. Nat Chem Biol. 2007. PMID: 17710090 No abstract available.
Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development.
Takeuchi JK, Mileikovskaia M, Koshiba-Takeuchi K, Heidt AB, Mori AD, Arruda EP, Gertsenstein M, Georges R, Davidson L, Mo R, Hui CC, Henkelman RM, Nemer M, Black BL, Nagy A, Bruneau BG. Takeuchi JK, et al. Among authors: heidt ab. Development. 2005 May;132(10):2463-74. doi: 10.1242/dev.01827. Epub 2005 Apr 20. Development. 2005. PMID: 15843409
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