Heikal A - Search Results

1

Oxidative Phosphorylation as a Target Space for Tuberculosis: Success, Caution, and Future Directions.

Cook GM, Hards K, Dunn E, Heikal A, Nakatani Y, Greening C, Crick DC, Fontes FL, Pethe K, Hasenoehrl E, Berney M. Cook GM, et al. Among authors: heikal a. Microbiol Spectr. 2017 Jun;5(3):10.1128/microbiolspec.TBTB2-0014-2016. doi: 10.1128/microbiolspec.TBTB2-0014-2016. Microbiol Spectr. 2017. PMID: 28597820 Free PMC article. Review.

2

Bridging the gap between a TB drug and its target.

Cook GM, Heikal A. Cook GM, et al. Among authors: heikal a. Sci Transl Med. 2012 Sep 5;4(150):150fs33. doi: 10.1126/scitranslmed.3004816. Sci Transl Med. 2012. PMID: 22956196

3

Regulation of proline metabolism in mycobacteria and its role in carbon metabolism under hypoxia.

Berney M, Weimar MR, Heikal A, Cook GM. Berney M, et al. Among authors: heikal a. Mol Microbiol. 2012 May;84(4):664-81. doi: 10.1111/j.1365-2958.2012.08053.x. Epub 2012 Apr 16. Mol Microbiol. 2012. PMID: 22507203 Free article.

4

Structure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generation.

Heikal A, Nakatani Y, Dunn E, Weimar MR, Day CL, Baker EN, Lott JS, Sazanov LA, Cook GM. Heikal A, et al. Mol Microbiol. 2014 Mar;91(5):950-64. doi: 10.1111/mmi.12507. Epub 2014 Jan 21. Mol Microbiol. 2014. PMID: 24444429 Free article.

5

Incorporation of triphenylphosphonium functionality improves the inhibitory properties of phenothiazine derivatives in Mycobacterium tuberculosis.

Dunn EA, Roxburgh M, Larsen L, Smith RA, McLellan AD, Heikal A, Murphy MP, Cook GM. Dunn EA, et al. Among authors: heikal a. Bioorg Med Chem. 2014 Oct 1;22(19):5320-8. doi: 10.1016/j.bmc.2014.07.050. Epub 2014 Aug 7. Bioorg Med Chem. 2014. PMID: 25150092

6

Comparison of lipid and detergent enzyme environments for identifying inhibitors of membrane-bound energy-transducing proteins.

Dunn EA, Cook GM, Heikal A. Dunn EA, et al. Among authors: heikal a. J Microbiol Methods. 2016 Jan;120:41-3. doi: 10.1016/j.mimet.2015.11.012. Epub 2015 Nov 28. J Microbiol Methods. 2016. PMID: 26593449

7

Activation of type II NADH dehydrogenase by quinolinequinones mediates antitubercular cell death.

Heikal A, Hards K, Cheung CY, Menorca A, Timmer MS, Stocker BL, Cook GM. Heikal A, et al. J Antimicrob Chemother. 2016 Oct;71(10):2840-7. doi: 10.1093/jac/dkw244. Epub 2016 Jun 30. J Antimicrob Chemother. 2016. PMID: 27365187

8

Annotated compound data for modulators of detergent-solubilised or lipid-reconstituted respiratory type II NADH dehydrogenase activity obtained by compound library screening.

Dunn EA, Cook GM, Heikal A. Dunn EA, et al. Among authors: heikal a. Data Brief. 2015 Dec 17;6:275-8. doi: 10.1016/j.dib.2015.12.019. eCollection 2016 Mar. Data Brief. 2015. PMID: 26862571 Free PMC article.

9

Multiple Bactericidal Mechanisms of the Zinc Ionophore PBT2.

Harbison-Price N, Ferguson SA, Heikal A, Taiaroa G, Hards K, Nakatani Y, Rennison D, Brimble MA, El-Deeb IM, Bohlmann L, McDevitt CA, von Itzstein M, Walker MJ, Cook GM. Harbison-Price N, et al. Among authors: heikal a. mSphere. 2020 Mar 18;5(2):e00157-20. doi: 10.1128/mSphere.00157-20. mSphere. 2020. PMID: 32188750 Free PMC article.

10

The mechanism of catalysis by type-II NADH:quinone oxidoreductases.

Blaza JN, Bridges HR, Aragão D, Dunn EA, Heikal A, Cook GM, Nakatani Y, Hirst J. Blaza JN, et al. Among authors: heikal a. Sci Rep. 2017 Jan 9;7:40165. doi: 10.1038/srep40165. Sci Rep. 2017. PMID: 28067272 Free PMC article.

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