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Role for monoamine oxidase-A (MAO-A) in the bioactivation and nigrostriatal dopaminergic neurotoxicity of the MPTP analog, 2'Me-MPTP.
Kindt MV, Youngster SK, Sonsalla PK, Duvoisin RC, Heikkila RE. Kindt MV, et al. Eur J Pharmacol. 1988 Feb 9;146(2-3):313-8. doi: 10.1016/0014-2999(88)90308-1. Eur J Pharmacol. 1988. PMID: 3131149
Attenuation by dopamine uptake blockers of the inhibitory effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and some of its analogs on NADH-linked metabolism in mouse neostriatal slices.
Ofori S, Heikkila RE, Nicklas WJ. Ofori S, et al. J Pharmacol Exp Ther. 1989 Oct;251(1):258-66. J Pharmacol Exp Ther. 1989. PMID: 2571719
Dopaminergic neurotoxicity of 1-methyl-4-phenylpyridinium analogs in cultured neurons: relationship to the dopamine uptake system and inhibition of mitochondrial respiration.
Saporito MS, Heikkila RE, Youngster SK, Nicklas WJ, Geller HM. Saporito MS, et al. Among authors: heikkila re. J Pharmacol Exp Ther. 1992 Mar;260(3):1400-9. J Pharmacol Exp Ther. 1992. PMID: 1312170
1-Methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine (2'-CH3-MPTP) is a more potent dopaminergic neurotoxin than MPTP in mice.
Youngster SK, Duvoisin RC, Hess A, Sonsalla PK, Kindt MV, Heikkila RE. Youngster SK, et al. Eur J Pharmacol. 1986 Mar 18;122(2):283-7. doi: 10.1016/0014-2999(86)90115-9. Eur J Pharmacol. 1986. PMID: 3486770
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