Heimark D - Search Results

1

Decreased myo-inositol to chiro-inositol (M/C) ratios and increased M/C epimerase activity in PCOS theca cells demonstrate increased insulin sensitivity compared to controls.

Heimark D, McAllister J, Larner J. Heimark D, et al. Endocr J. 2014;61(2):111-7. doi: 10.1507/endocrj.ej13-0423. Epub 2013 Nov 2. Endocr J. 2014. PMID: 24189751 Free article.

2

Chronic treatment with D-chiro-inositol prevents autonomic and somatic neuropathy in STZ-induced diabetic mice.

Farias VX, Macêdo FH, Oquendo MB, Tomé AR, Báo SN, Cintra DO, Santos CF, Albuquerque AA, Heimark DB, Larner J, Fonteles MC, Leal-Cardoso JH, Nascimento NR. Farias VX, et al. Among authors: heimark db. Diabetes Obes Metab. 2011 Mar;13(3):243-50. doi: 10.1111/j.1463-1326.2010.01344.x. Diabetes Obes Metab. 2011. PMID: 21205116

3

Both myo-inositol to chiro-inositol epimerase activities and chiro-inositol to myo-inositol ratios are decreased in tissues of GK type 2 diabetic rats compared to Wistar controls.

Sun TH, Heimark DB, Nguygen T, Nadler JL, Larner J. Sun TH, et al. Among authors: heimark db. Biochem Biophys Res Commun. 2002 May 10;293(3):1092-8. doi: 10.1016/S0006-291X(02)00313-3. Biochem Biophys Res Commun. 2002. PMID: 12051772

4

Isolation, structure, synthesis, and bioactivity of a novel putative insulin mediator. A galactosamine chiro-inositol pseudo-disaccharide Mn2+ chelate with insulin-like activity.

Larner J, Price JD, Heimark D, Smith L, Rule G, Piccariello T, Fonteles MC, Pontes C, Vale D, Huang L. Larner J, et al. Among authors: heimark d. J Med Chem. 2003 Jul 17;46(15):3283-91. doi: 10.1021/jm030071j. J Med Chem. 2003. PMID: 12852758

5

Allosteric activation of protein phosphatase 2C by D-chiro-inositol-galactosamine, a putative mediator mimetic of insulin action.

Brautigan DL, Brown M, Grindrod S, Chinigo G, Kruszewski A, Lukasik SM, Bushweller JH, Horal M, Keller S, Tamura S, Heimark DB, Price J, Larner AN, Larner J. Brautigan DL, et al. Among authors: heimark db. Biochemistry. 2005 Aug 23;44(33):11067-73. doi: 10.1021/bi0508845. Biochemistry. 2005. PMID: 16101290

6

G(q/11) is involved in insulin-stimulated inositol phosphoglycan putative mediator generation in rat liver membranes: co-localization of G(q/11) with the insulin receptor in membrane vesicles.

Sleight S, Wilson BA, Heimark DB, Larner J. Sleight S, et al. Among authors: heimark db. Biochem Biophys Res Commun. 2002 Jul 12;295(2):561-9. doi: 10.1016/s0006-291x(02)00701-5. Biochem Biophys Res Commun. 2002. PMID: 12150987

7

Duality in the mechanism of action of insulin.

Larner J, Romero G, Kennington AS, Lilley K, Kilgour E, Zhang C, Heimark D, Gamez G, Houston DB, Huang LC. Larner J, et al. Among authors: heimark d. Adv Second Messenger Phosphoprotein Res. 1990;24:290-4. Adv Second Messenger Phosphoprotein Res. 1990. PMID: 2169809 No abstract available.

8

A model phosphatase 2C --> phosphatase 1 activation cascade via dual control of inhibitor-1 (INH-1) and DARPP-32 dephosphorylation by two inositol glycan putative insulin mediators from beef liver.

Huang LC, Heimark D, Linko J, Nolan R, Larner J. Huang LC, et al. Among authors: heimark d. Biochem Biophys Res Commun. 1999 Feb 5;255(1):150-6. doi: 10.1006/bbrc.1999.0111. Biochem Biophys Res Commun. 1999. PMID: 10082671

9

Expression of myo-inositol cotransporters in the sciatic nerve and dorsal root ganglia in experimental diabetes.

Farias VX, Uchoa PN, Aquino CP, Britto LRG, Fonteles MC, Leal-Cardoso JH, Silva-Alves KS, Havt A, Prata MMG, Heimark DB, Nascimento NRF, Santos CF. Farias VX, et al. Among authors: heimark db. Braz J Med Biol Res. 2019;52(6):e8589. doi: 10.1590/1414-431x20198589. Epub 2019 Jun 3. Braz J Med Biol Res. 2019. PMID: 31166385 Free PMC article.

10

Inositols prevent and reverse endothelial dysfunction in diabetic rat and rabbit vasculature metabolically and by scavenging superoxide.

Nascimento NR, Lessa LM, Kerntopf MR, Sousa CM, Alves RS, Queiroz MG, Price J, Heimark DB, Larner J, Du X, Brownlee M, Gow A, Davis C, Fonteles MC. Nascimento NR, et al. Among authors: heimark db. Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):218-23. doi: 10.1073/pnas.0509779103. Epub 2005 Dec 22. Proc Natl Acad Sci U S A. 2006. PMID: 16373499 Free PMC article.

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