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Formerly degenerate seventh zinc finger domain from transcription factor ZNF711 rehabilitated by experimental NMR structure.
Rua AJ, Alexandrescu AT. Rua AJ, et al. bioRxiv [Preprint]. 2024 Apr 10:2024.04.06.588434. doi: 10.1101/2024.04.06.588434. bioRxiv. 2024. PMID: 38645208 Free PMC article. Preprint.
Mutagenesis and pH titration experiments indicate that H26 is not involved in metal binding and that Z7 has a tridentate metal-binding site comprised of only residues C3, C6, and H19. By contrast, an F23H mutation that introduces a histidine in the consensus position forms …
Mutagenesis and pH titration experiments indicate that H26 is not involved in metal binding and that Z7 has a tridentate metal-binding site …
Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021.
GBD 2021 Diseases and Injuries Collaborators. GBD 2021 Diseases and Injuries Collaborators. Lancet. 2024 Apr 15:S0140-6736(24)00757-8. doi: 10.1016/S0140-6736(24)00757-8. Online ahead of print. Lancet. 2024. PMID: 38642570
The Effect of C2 Muscular Exposure Technique on Radiographic and Clinical Outcomes After C2-T2 Posterior Cervical Fusion.
Levy HA, Pinter ZW, Pumford A, Salmons HI, Townsley S, Katsos K, Reed R, Chen S, Abode-Iyamah K, Deen HG, Clarke M, Bydon M, Fogelson JL, Elder BD, Currier B, Freedman BA, Nassr AN, Karamian BA, Sebastian AS. Levy HA, et al. Clin Spine Surg. 2024 Apr 10. doi: 10.1097/BSD.0000000000001626. Online ahead of print. Clin Spine Surg. 2024. PMID: 38637921
Preoperative to postoperative changes in C2 slope, C2 tilt, C2-C3 segmental lordosis, C2-C3 listhesis, C0-C2 Cobb angle, proximal junctional kyphosis, ADI, C1 lamina-occiput distance, C2 sagittal vertical axis, C2-C7 lordosis, and PROMs at all follow-up intervals di …
Preoperative to postoperative changes in C2 slope, C2 tilt, C2-C3 segmental lordosis, C2-C3 listhesis, C0-C2 Cobb angle, proxi …
Artemyriantholides A-K, guaiane-type sesquiterpenoid dimers from Artemisia myriantha var. pleiocephala and their antihepatoma activity.
Wang MF, Li TZ, Ma YB, Ma WJ, Wang YC, Li FJ, Chen JJ. Wang MF, et al. Phytochemistry. 2024 Apr 16;222:114100. doi: 10.1016/j.phytochem.2024.114100. Online ahead of print. Phytochemistry. 2024. PMID: 38636688
The interaction between compound 5 and MAP2K2 was conducted to give docking score of -9.0 kcal/mol by molecular docking and provide K(D) value of 43.7 muM by Surface Plasmon Resonance assay....
The interaction between compound 5 and MAP2K2 was conducted to give docking score of -9.0 kcal/mol by molecular docking and provide K(D …
First evidence for human occupation of a lava tube in Arabia: The archaeology of Umm Jirsan Cave and its surroundings, northern Saudi Arabia.
Stewart M, Andrieux E, Blinkhorn J, Guagnin M, Fernandes R, Vanwezer N, Hatton A, Alqahtani M, Zalmout I, Clark-Wilson R, Al-Mufarreh YSA, Al-Shanti M, Zahrani B, Al Omari A, Al-Jibreen F, Alsharekh AM, Scerri EML, Boivin N, Petraglia MD, Groucutt HS. Stewart M, et al. PLoS One. 2024 Apr 17;19(4):e0299292. doi: 10.1371/journal.pone.0299292. eCollection 2024. PLoS One. 2024. PMID: 38630666 Free PMC article.
Isotopic data indicates that herbivores primarily grazed on wild grasses and shrubs rather than being provided with fodder, while humans had a diet consistently high in protein but with increasing consumption of C3 plants through-time, perhaps related to the emergence of o …
Isotopic data indicates that herbivores primarily grazed on wild grasses and shrubs rather than being provided with fodder, while humans had …
Lung Tissue Multi-Layer Network Analysis Uncovers the Molecular Heterogeneity of COPD.
Olvera N, Sánchez-Valle J, Núñez-Carpintero I, Rojas-Quintero J, Noell G, Casas-Recasens S, Faiz A, Hansbro P, Guirao A, Lepore R, Cirillo D, Agustí A, Polverino F, Valencia A, Faner R. Olvera N, et al. Am J Respir Crit Care Med. 2024 Apr 16. doi: 10.1164/rccm.202303-0500OC. Online ahead of print. Am J Respir Crit Care Med. 2024. PMID: 38626356
Complement inhibition in paroxysmal nocturnal hemoglobinuria: From biology to therapy.
Versino F, Fattizzo B. Versino F, et al. Int J Lab Hematol. 2024 Apr 15. doi: 10.1111/ijlh.14281. Online ahead of print. Int J Lab Hematol. 2024. PMID: 38622956 Review.
Additionally, suboptimal response may occur in up to 2/3 of patients with persistent anemia due to incomplete control of intravascular hemolysis, development of upstream C3-mediated extravascular hemolysis (EVH), or concomitant bone marrow failure. ...Upstream inhibition o …
Additionally, suboptimal response may occur in up to 2/3 of patients with persistent anemia due to incomplete control of intravascular hemol …
Sucrose esters of aryldihydronaphthalene-type lignans, and antitumor activity of extracts of Moltkiopsis ciliata (Forssk.) aerial parts.
Youssef Moustafa AM, Abdel-Moneim M, Mostafa ME, Abdel-Mogib M, Rabee Abdel-Hak M. Youssef Moustafa AM, et al. Nat Prod Res. 2024 Apr 11:1-11. doi: 10.1080/14786419.2024.2341307. Online ahead of print. Nat Prod Res. 2024. PMID: 38600852
One new compound (3f-[(7'R,8'R)-4,4'-dihydroxy-5-methoxy-2,7'-cycloligna-7-en-9-methoxycarbonyl, 9'-carbonyl-O-] -beta- D-fructofuranosyl- (21)-alpha- D-glucopyranoside) (Moltkiopsin A) (2) was isolated and identified from the extract of aerial parts of the wild Egy …
One new compound (3f-[(7'R,8'R)-4,4'-dihydroxy-5-methoxy-2,7'-cycloligna-7-en-9-methoxycarbonyl, 9'-carbonyl-O-] -beta- D-fructofuran …
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