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Reduced cell proliferation and increased apoptosis are significant pathological mechanisms in a murine model of mild pseudoachondroplasia resulting from a mutation in the C-terminal domain of COMP.
Piróg-Garcia KA, Meadows RS, Knowles L, Heinegård D, Thornton DJ, Kadler KE, Boot-Handford RP, Briggs MD. Piróg-Garcia KA, et al. Among authors: heinegard d. Hum Mol Genet. 2007 Sep 1;16(17):2072-88. doi: 10.1093/hmg/ddm155. Epub 2007 Jun 22. Hum Mol Genet. 2007. PMID: 17588960 Free PMC article.
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