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Timing between the subcutaneous administration of insulin and consumption of a carbohydrate rich meal.
Heinemann L, Starke AA, Hohmann A, Berger M. Heinemann L, et al. Horm Metab Res Suppl. 1992;26:137-9. Horm Metab Res Suppl. 1992. PMID: 1490682
There is considerable uncertainty as to the appropriate timing of preprandial injections of short acting insulin before consumption of a meal. 8 healthy male volunteers were subjected to a glucose clamp (glucose 4.2 mmol/l) by means of a continuous insulin infusion on two …
There is considerable uncertainty as to the appropriate timing of preprandial injections of short acting insulin before consumption of a mea …
Atrial natriuretic factor in various stages of diabetic nephropathy.
Sawicki PT, Heinemann L, Rave K, Hohmann A, Berger M. Sawicki PT, et al. J Diabet Complications. 1988 Oct-Dec;2(4):207-9. doi: 10.1016/s0891-6632(88)80010-2. J Diabet Complications. 1988. PMID: 2976764
Pharmacokinetics and linear exposure of AFRESA compared with the subcutaneous injection of regular human insulin.
Rave K, Potocka E, Heinemann L, Heise T, Boss AH, Marino M, Costello D, Chen R. Rave K, et al. Diabetes Obes Metab. 2009 Jul;11(7):715-20. doi: 10.1111/j.1463-1326.2009.01039.x. Epub 2009 May 19. Diabetes Obes Metab. 2009. PMID: 19476477 Clinical Trial.
Prandial glycaemia after a carbohydrate-rich meal in type I diabetic patients: using the rapid acting insulin analogue [Lys(B28), Pro(B29)] human insulin.
Heinemann L, Heise T, Wahl LC, Trautmann ME, Ampudia J, Starke AA, Berger M. Heinemann L, et al. Diabet Med. 1996 Jul;13(7):625-9. doi: 10.1002/(SICI)1096-9136(199607)13:7<625::AID-DIA134>3.0.CO;2-2. Diabet Med. 1996. PMID: 8840095 Clinical Trial.

Following the injection of insulin lispro the area under the blood glucose curve after the meal was 78% of that of regular insulin (1.76 +/- 0.34 vs 2.26 +/- 0.68 mol l-1 *240 min-1; p < 0.01). ...Maximal individual differences in the blood glucose excursions (regular h

Following the injection of insulin lispro the area under the blood glucose curve after the meal was 78% of that of regular insulin (1.76 +/- …
Short-term evaluation of an electro-chemical system (ExacTech) for blood glucose monitoring.
Ross D, Heinemann L, Chantelau EA. Ross D, et al. Diabetes Res Clin Pract. 1990 Nov-Dec;10(3):281-5. doi: 10.1016/0168-8227(90)90071-z. Diabetes Res Clin Pract. 1990. PMID: 2073875
The mean differences between the pen-meters' blood glucose readings and plasma glucose were -1.35, -1.43 and -1.56 mmol/l, with limits of agreement (+/- 2 SD) of 2.2 and -4.9, 2.1 and -5.0 and 2.0 and -5.1 mmol/l, respectively. The 57 samples in the clinically relev …
The mean differences between the pen-meters' blood glucose readings and plasma glucose were -1.35, -1.43 and -1.56 mmol/l, with limit …
Hypoglycemia and insulin analogues: is there a reduction in the incidence?
Heinemann L. Heinemann L. J Diabetes Complications. 1999 Mar-Apr;13(2):105-14. doi: 10.1016/s1056-8727(99)00031-8. J Diabetes Complications. 1999. PMID: 10432175 Review.
Impact of diabetic nephropathy on pharmacodynamic and Pharmacokinetic properties of insulin in type 1 diabetic patients.
Rave K, Heise T, Pfützner A, Heinemann L, Sawicki PT. Rave K, et al. Diabetes Care. 2001 May;24(5):886-90. doi: 10.2337/diacare.24.5.886. Diabetes Care. 2001. PMID: 11347749
RESEARCH DESIGN AND METHODS: In this double-blind, two-way cross-over, euglycemic (5 mmol/l) glucose clamp study, we investigated the metabolic response to subcutaneous injections of regular insulin and insulin lispro (0.2 U/kg) in 12 type 1 diabetic patients with overt di …
RESEARCH DESIGN AND METHODS: In this double-blind, two-way cross-over, euglycemic (5 mmol/l) glucose clamp study, we investigated the …
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