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Structural organization of the bcr gene and its role in the Ph' translocation.
Heisterkamp N, Stam K, Groffen J, de Klein A, Grosveld G. Heisterkamp N, et al. Nature. 1985 Jun 27-Jul 3;315(6022):758-61. doi: 10.1038/315758a0. Nature. 1985. PMID: 2989703
BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition.
Duy C, Hurtz C, Shojaee S, Cerchietti L, Geng H, Swaminathan S, Klemm L, Kweon SM, Nahar R, Braig M, Park E, Kim YM, Hofmann WK, Herzog S, Jumaa H, Koeffler HP, Yu JJ, Heisterkamp N, Graeber TG, Wu H, Ye BH, Melnick A, Müschen M. Duy C, et al. Nature. 2011 May 19;473(7347):384-8. doi: 10.1038/nature09883. Nature. 2011. PMID: 21593872 Free PMC article.
Duplication of the bcr and gamma-glutamyl transpeptidase genes.
Heisterkamp N, Groffen J. Heisterkamp N, et al. Nucleic Acids Res. 1988 Aug 25;16(16):8045-56. doi: 10.1093/nar/16.16.8045. Nucleic Acids Res. 1988. PMID: 2901712 Free PMC article.
Unique organization of the human BCR gene promoter.
Zhu QS, Heisterkamp N, Groffen J. Zhu QS, et al. Nucleic Acids Res. 1990 Dec 11;18(23):7119-25. doi: 10.1093/nar/18.23.7119. Nucleic Acids Res. 1990. PMID: 2263470 Free PMC article.
A complex chromosome rearrangement forms the BCR-ABL fusion gene in leukemic cells with a normal karyotype.
Morris C, Kennedy M, Heisterkamp N, Columbano-Green L, Romeril K, Groffen J, Fitzgerald P. Morris C, et al. Genes Chromosomes Cancer. 1991 Jul;3(4):263-71. doi: 10.1002/gcc.2870030405. Genes Chromosomes Cancer. 1991. PMID: 1958592
A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukaemia.
Chan LC, Karhi KK, Rayter SI, Heisterkamp N, Eridani S, Powles R, Lawler SD, Groffen J, Foulkes JG, Greaves MF, Wiedemann LM. Chan LC, et al. Nature. 1987 Feb 12-18;325(6105):635-7. doi: 10.1038/325635a0. Nature. 1987. PMID: 3027581
The BCR/ABL hybrid gene.
Groffen J, Heisterkamp N. Groffen J, et al. Baillieres Clin Haematol. 1987 Dec;1(4):983-99. doi: 10.1016/s0950-3536(87)80035-5. Baillieres Clin Haematol. 1987. PMID: 3332859 Review.
Evidence of a new chimeric bcr/c-abl mRNA in patients with chronic myelocytic leukemia and the Philadelphia chromosome.
Stam K, Heisterkamp N, Grosveld G, de Klein A, Verma RS, Coleman M, Dosik H, Groffen J. Stam K, et al. N Engl J Med. 1985 Dec 5;313(23):1429-33. doi: 10.1056/NEJM198512053132301. N Engl J Med. 1985. PMID: 3864009
C-abl and bcr are rearranged in a Ph1-negative CML patient.
Bartram CR, Kleihauer E, de Klein A, Grosveld G, Teyssier JR, Heisterkamp N, Groffen J. Bartram CR, et al. EMBO J. 1985 Mar;4(3):683-6. EMBO J. 1985. PMID: 3859408 Free PMC article.
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