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FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity.
Cardenas ME, Heitman J. Cardenas ME, et al. Among authors: heitman j. EMBO J. 1995 Dec 1;14(23):5892-907. EMBO J. 1995. PMID: 8846782 Free PMC article.
Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast.
Heitman J, Movva NR, Hall MN. Heitman J, et al. Science. 1991 Aug 23;253(5022):905-9. doi: 10.1126/science.1715094. Science. 1991. PMID: 1715094
TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin.
Lorenz MC, Heitman J. Lorenz MC, et al. Among authors: heitman j. J Biol Chem. 1995 Nov 17;270(46):27531-7. doi: 10.1074/jbc.270.46.27531. J Biol Chem. 1995. PMID: 7499212
Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains.
Breuder T, Hemenway CS, Movva NR, Cardenas ME, Heitman J. Breuder T, et al. Among authors: heitman j. Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5372-6. doi: 10.1073/pnas.91.12.5372. Proc Natl Acad Sci U S A. 1994. PMID: 7515500 Free PMC article.
Antifungal effects of cyclosporine and FK 506 are mediated via immunophilin-dependent calcineurin inhibition.
Heitman J, Cardenas ME, Breuder T, Hemenway C, Muir RS, Lim E, Goetz L, Zhu D, Lorenz M, Dolinski K. Heitman J, et al. Transplant Proc. 1994 Oct;26(5):2833-4. Transplant Proc. 1994. PMID: 7524220 No abstract available.
Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands.
Cardenas ME, Hemenway C, Muir RS, Ye R, Fiorentino D, Heitman J. Cardenas ME, et al. Among authors: heitman j. EMBO J. 1994 Dec 15;13(24):5944-57. EMBO J. 1994. PMID: 7529175 Free PMC article.
Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A.
Cardenas ME, Muir RS, Breuder T, Heitman J. Cardenas ME, et al. Among authors: heitman j. EMBO J. 1995 Jun 15;14(12):2772-83. EMBO J. 1995. PMID: 7540976 Free PMC article.
Myristoylation of calcineurin B is not required for function or interaction with immunophilin-immunosuppressant complexes in the yeast Saccharomyces cerevisiae.
Zhu D, Cardenas ME, Heitman J. Zhu D, et al. Among authors: heitman j. J Biol Chem. 1995 Oct 20;270(42):24831-8. doi: 10.1074/jbc.270.42.24831. J Biol Chem. 1995. PMID: 7559604
Mutations that perturb cyclophilin A ligand binding pocket confer cyclosporin A resistance in Saccharomyces cerevisiae.
Cardenas ME, Lim E, Heitman J. Cardenas ME, et al. Among authors: heitman j. J Biol Chem. 1995 Sep 8;270(36):20997-1002. doi: 10.1074/jbc.270.36.20997. J Biol Chem. 1995. PMID: 7673124
Gene disruption with PCR products in Saccharomyces cerevisiae.
Lorenz MC, Muir RS, Lim E, McElver J, Weber SC, Heitman J. Lorenz MC, et al. Among authors: heitman j. Gene. 1995 May 26;158(1):113-7. doi: 10.1016/0378-1119(95)00144-u. Gene. 1995. PMID: 7789793
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