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Fast Iterative Synthetic Approach toward Identification of Novel Highly Selective p38 MAP Kinase Inhibitors.
J Med Chem. 2019 Dec 12;62(23):10757-10782. doi: 10.1021/acs.jmedchem.9b01227. Epub 2019 Nov 26.
J Med Chem. 2019.
PMID: 31702918
Discovery of 2,4-1H-Imidazole Carboxamides as Potent and Selective TAK1 Inhibitors.
Veerman JJN, Bruseker YB, Damen E, Heijne EH, van Bruggen W, Hekking KFW, Winkel R, Hupp CD, Keefe AD, Liu J, Thomson HA, Zhang Y, Cuozzo JW, McRiner AJ, Mulvihill MJ, van Rijnsbergen P, Zech B, Renzetti LM, Babiss L, Müller G.
Veerman JJN, et al. Among authors: hekking kfw.
ACS Med Chem Lett. 2021 Mar 3;12(4):555-562. doi: 10.1021/acsmedchemlett.0c00547. eCollection 2021 Apr 8.
ACS Med Chem Lett. 2021.
PMID: 33859795
Free PMC article.
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Development of Potent Mcl-1 Inhibitors: Structural Investigations on Macrocycles Originating from a DNA-Encoded Chemical Library Screen.
Hekking KFW, Maroto S, van Kekem K, Haasjes FS, Slootweg JC, Oude Alink PGB, Dirks R, Sardana M, Bolster MG, Kuijpers B, Smith D, Doodeman R, Scheepstra M, Zech B, Mulvihill M, Renzetti LM, Babiss L, Centrella PA, Clark MA, Cuozzo JW, Guié MA, Sigel E, Habeshian S, Hupp CD, Liu J, Thomson HA, Zhang Y, Keefe AD, Müller G, Gremmen S.
Hekking KFW, et al.
J Med Chem. 2024 Feb 22;67(4):3039-3065. doi: 10.1021/acs.jmedchem.3c02206. Epub 2024 Feb 2.
J Med Chem. 2024.
PMID: 38306405
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Bivalent Ligands for Protein Degradation in Drug Discovery.
Scheepstra M, Hekking KFW, van Hijfte L, Folmer RHA.
Scheepstra M, et al. Among authors: hekking kfw.
Comput Struct Biotechnol J. 2019 Jan 25;17:160-176. doi: 10.1016/j.csbj.2019.01.006. eCollection 2019.
Comput Struct Biotechnol J. 2019.
PMID: 30788082
Free PMC article.
Review.
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An in-depth study on ring-closing metathesis of carbohydrate-derived alpha-alkoxyacrylates: efficient syntheses of DAH, KDO, and 2-deoxy-beta-KDO.
Hekking KF, Moelands MA, van Delft FL, Rutjes FP.
Hekking KF, et al.
J Org Chem. 2006 Aug 18;71(17):6444-50. doi: 10.1021/jo060913x.
J Org Chem. 2006.
PMID: 16901129
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