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Histone demethylases in development and disease.
Pedersen MT, Helin K. Pedersen MT, et al. Among authors: helin k. Trends Cell Biol. 2010 Nov;20(11):662-71. doi: 10.1016/j.tcb.2010.08.011. Epub 2010 Sep 20. Trends Cell Biol. 2010. PMID: 20863703 Review.
Translational control and differential RNA decay are key elements regulating postsegregational expression of the killer protein encoded by the parB locus of plasmid R1.
Gerdes K, Helin K, Christensen OW, Løbner-Olesen A. Gerdes K, et al. Among authors: helin k. J Mol Biol. 1988 Sep 5;203(1):119-29. doi: 10.1016/0022-2836(88)90096-4. J Mol Biol. 1988. PMID: 2460630
Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription.
Christensen J, Cloos P, Toftegaard U, Klinkenberg D, Bracken AP, Trinh E, Heeran M, Di Stefano L, Helin K. Christensen J, et al. Among authors: helin k. Nucleic Acids Res. 2005 Sep 22;33(17):5458-70. doi: 10.1093/nar/gki855. Print 2005. Nucleic Acids Res. 2005. PMID: 16179649 Free PMC article.
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions.
Bracken AP, Dietrich N, Pasini D, Hansen KH, Helin K. Bracken AP, et al. Among authors: helin k. Genes Dev. 2006 May 1;20(9):1123-36. doi: 10.1101/gad.381706. Epub 2006 Apr 17. Genes Dev. 2006. PMID: 16618801 Free PMC article.
The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3.
Cloos PA, Christensen J, Agger K, Maiolica A, Rappsilber J, Antal T, Hansen KH, Helin K. Cloos PA, et al. Among authors: helin k. Nature. 2006 Jul 20;442(7100):307-11. doi: 10.1038/nature04837. Epub 2006 May 28. Nature. 2006. PMID: 16732293
RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3.
Christensen J, Agger K, Cloos PA, Pasini D, Rose S, Sennels L, Rappsilber J, Hansen KH, Salcini AE, Helin K. Christensen J, et al. Among authors: helin k. Cell. 2007 Mar 23;128(6):1063-76. doi: 10.1016/j.cell.2007.02.003. Epub 2007 Feb 22. Cell. 2007. PMID: 17320161
Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus.
Dietrich N, Bracken AP, Trinh E, Schjerling CK, Koseki H, Rappsilber J, Helin K, Hansen KH. Dietrich N, et al. Among authors: helin k. EMBO J. 2007 Mar 21;26(6):1637-48. doi: 10.1038/sj.emboj.7601632. Epub 2007 Mar 1. EMBO J. 2007. PMID: 17332741 Free PMC article.
The polycomb group protein Suz12 is required for embryonic stem cell differentiation.
Pasini D, Bracken AP, Hansen JB, Capillo M, Helin K. Pasini D, et al. Among authors: helin k. Mol Cell Biol. 2007 May;27(10):3769-79. doi: 10.1128/MCB.01432-06. Epub 2007 Mar 5. Mol Cell Biol. 2007. PMID: 17339329 Free PMC article.
The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells.
Bracken AP, Kleine-Kohlbrecher D, Dietrich N, Pasini D, Gargiulo G, Beekman C, Theilgaard-Mönch K, Minucci S, Porse BT, Marine JC, Hansen KH, Helin K. Bracken AP, et al. Among authors: helin k. Genes Dev. 2007 Mar 1;21(5):525-30. doi: 10.1101/gad.415507. Genes Dev. 2007. PMID: 17344414 Free PMC article.
UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development.
Agger K, Cloos PA, Christensen J, Pasini D, Rose S, Rappsilber J, Issaeva I, Canaani E, Salcini AE, Helin K. Agger K, et al. Among authors: helin k. Nature. 2007 Oct 11;449(7163):731-4. doi: 10.1038/nature06145. Epub 2007 Aug 22. Nature. 2007. PMID: 17713478
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