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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 1
1982 1
1983 1
1984 1
1986 2
1988 2
1989 4
1991 2
1992 2
1993 5
1994 6
1995 5
1996 10
1997 12
1998 16
1999 9
2000 2
2001 5
2002 5
2003 4
2004 4
2005 4
2006 2
2007 4
2008 4
2009 3
2010 1
2011 1
2012 1
2015 1
2017 1
2020 1
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114 results
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Page 1
Phosphodiesterase (PDE)4 inhibitors: anti-inflammatory drugs of the future?
Teixeira MM, et al. Trends Pharmacol Sci 1997 - Review. Among authors: Hellewell PG. PMID 9184477
In this review, Mauro Teixeira, Robert Gristwood, Nicola Cooper and Paul Hellewell examine the capacity of PDE4 inhibitors to exert anti-inflammatory actions in vivo and discuss the potential of this class of drugs to take their place as novel therapeutic agents for a variety of inflammatory diseases....
In this review, Mauro Teixeira, Robert Gristwood, Nicola Cooper and Paul Hellewell examine the capacity of PDE4 inhibitors to exert a …
L- and P-selectins collaborate to support leukocyte rolling in vivo when high-affinity P-selectin-P-selectin glycoprotein ligand-1 interaction is inhibited.
Ridger VC, et al. Am J Pathol 2005. Among authors: Hellewell PG. PMID 15743805 Free PMC article.
P-selectin glycoprotein ligand-1 (PSGL-1) binding to P-selectin controls early leukocyte rolling during inflammation. Interestingly, antibodies and pharmacological inhibitors (eg, rPSGL-Ig) that target the N-terminus of PSGL-1 reduce but do not abolish P-selectin-dependent leukocyte rolling in vivo whereas PSGL-1-deficient mice have almost no P-selectin-dependent rolling. ...Together these data suggest that leukocytes can continue to roll in the absence of optimal P-selectin/PSGL-1 interaction using an alternative mechanism that involves P-selectin-, L-selectin-, and sLe(x)-bearing ligands....
P-selectin glycoprotein ligand-1 (PSGL-1) binding to P-selectin controls early leukocyte rolling during inflammation. Interest
Adhesion molecule strategies
Hellewell PG. Pulm Pharmacol Ther 1999 - Review. PMID 10373397
Atorvastatin reduces endotoxin-induced microvascular inflammation via NOSII
McGown CC, et al. Naunyn Schmiedebergs Arch Pharmacol 2015. Among authors: Hellewell PG. PMID 25678054
LPS decreased mean arterial blood pressure (MAP) (4 h, control 113 ± 20 mmHg; LPS 70 ± 23 mmHg), being reversed by atorvastatin (105 ± 3 mmHg) (p < 0.05). LPS also increased macromolecular leak measured after 100 mg kg(-1) of i.v FITC-BSA (arbitrary grey level adjacent to venules), which again was attenuated by atorvastatin (control 1.9 ± 4.0; LPS 12.0 ± 2.4; LPS + atorvastatin 4.5 ± 2.2) (p < 0.05). ...
LPS decreased mean arterial blood pressure (MAP) (4 h, control 113 ± 20 mmHg; LPS 70 ± 23 mmHg), being reversed by atorvastatin (105 ± 3 mmH …
Mechanisms and pharmacological manipulation of eosinophil accumulation in vivo
Teixeira MM, et al. Trends Pharmacol Sci 1995 - Review. Among authors: Hellewell PG. PMID 8578615
Here, Mauro Teixeira, Timothy Williams and Paul Hellewell describe the current concepts of eosinophil accumulation, examine the potential ways of modulating this process, and discuss whether antagonists of eosinophil-specific mediators or functional antagonists would be the preferred therapies....
Here, Mauro Teixeira, Timothy Williams and Paul Hellewell describe the current concepts of eosinophil accumulation, examine the poten …
Glycosulfopeptides modeled on P-selectin glycoprotein ligand 1 inhibit P-selectin-dependent leukocyte rolling in vivo.
Hicks AE, et al. FASEB J 2002. Among authors: Hellewell PG. PMID 12205048
Surgical preparation of the mouse cremaster muscle for intravital microscopy induced P-selectin-dependent leukocyte rolling. ...These data represent the first demonstration that a precisely defined structure based on a natural P-selectin ligand can inhibit P-selectin-dependent leukocyte rolling in vivo....
Surgical preparation of the mouse cremaster muscle for intravital microscopy induced P-selectin-dependent leukocyte rolling. ...These …
P-selectin glycoprotein ligand-1 supports rolling on E- and P-selectin in vivo.
Norman KE, et al. Blood 2000. Among authors: Hellewell PG. PMID 11071658
The best-characterized selectin ligand is P-selectin glycoprotein-1 (PSGL-1) that supports P-selectin- dependent rolling in vitro and in vivo. ...The results suggest that P-selectin-PSGL-1 interaction alone is sufficient to mediate rolling in vivo and that E-selectin-PSGL-1 interaction supports slow rolling....
The best-characterized selectin ligand is P-selectin glycoprotein-1 (PSGL-1) that supports P-selectin- dependent rolling in vi …
114 results
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