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The anti-oxidative transcription factor Nuclear factor E2 related factor-2 (Nrf2) counteracts TGF-β1 mediated growth inhibition of pancreatic ductal epithelial cells -Nrf2 as determinant of pro-tumorigenic functions of TGF-β1.
Genrich G, Kruppa M, Lenk L, Helm O, Broich A, Freitag-Wolf S, Röcken C, Sipos B, Schäfer H, Sebens S. Genrich G, et al. Among authors: helm o. BMC Cancer. 2016 Feb 25;16:155. doi: 10.1186/s12885-016-2191-7. BMC Cancer. 2016. PMID: 26915435 Free PMC article.
The antioxidant transcription factor Nrf2 modulates the stress response and phenotype of malignant as well as premalignant pancreatic ductal epithelial cells by inducing expression of the ATF3 splicing variant ΔZip2.
Kha ML, Hesse L, Deisinger F, Sipos B, Röcken C, Arlt A, Sebens S, Helm O, Schäfer H. Kha ML, et al. Among authors: helm o. Oncogene. 2019 Feb;38(9):1461-1476. doi: 10.1038/s41388-018-0518-3. Epub 2018 Oct 9. Oncogene. 2019. PMID: 30302023
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