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DMBT1 functions as pattern-recognition molecule for poly-sulfated and poly-phosphorylated ligands.
End C, Bikker F, Renner M, Bergmann G, Lyer S, Blaich S, Hudler M, Helmke B, Gassler N, Autschbach F, Ligtenberg AJ, Benner A, Holmskov U, Schirmacher P, Nieuw Amerongen AV, Rosenstiel P, Sina C, Franke A, Hafner M, Kioschis P, Schreiber S, Poustka A, Mollenhauer J. End C, et al. Among authors: helmke b. Eur J Immunol. 2009 Mar;39(3):833-42. doi: 10.1002/eji.200838689. Eur J Immunol. 2009. PMID: 19189310
DMBT1 confers mucosal protection in vivo and a deletion variant is associated with Crohn's disease.
Renner M, Bergmann G, Krebs I, End C, Lyer S, Hilberg F, Helmke B, Gassler N, Autschbach F, Bikker F, Strobel-Freidekind O, Gronert-Sum S, Benner A, Blaich S, Wittig R, Hudler M, Ligtenberg AJ, Madsen J, Holmskov U, Annese V, Latiano A, Schirmacher P, Amerongen AV, D'Amato M, Kioschis P, Hafner M, Poustka A, Mollenhauer J. Renner M, et al. Among authors: helmke b. Gastroenterology. 2007 Nov;133(5):1499-509. doi: 10.1053/j.gastro.2007.08.007. Epub 2007 Aug 3. Gastroenterology. 2007. PMID: 17983803
Carcinogen inducibility in vivo and down-regulation of DMBT1 during breast carcinogenesis.
Mollenhauer J, Helmke B, Medina D, Bergmann G, Gassler N, Müller H, Lyer S, Diedrichs L, Renner M, Wittig R, Blaich S, Hamann U, Madsen J, Holmskov U, Bikker F, Ligtenberg A, Carlén A, Olsson J, Otto HF, O'Malley B, Poustka A. Mollenhauer J, et al. Among authors: helmke b. Genes Chromosomes Cancer. 2004 Mar;39(3):185-94. doi: 10.1002/gcc.10309. Genes Chromosomes Cancer. 2004. PMID: 14732920
Frequent downregulation of DMBT1 and galectin-3 in epithelial skin cancer.
Mollenhauer J, Deichmann M, Helmke B, Müller H, Kollender G, Holmskov U, Ligtenberg T, Krebs I, Wiemann S, Bantel-Schaal U, Madsen J, Bikker F, Klauck SM, Otto HF, Moldenhauer G, Poustka A. Mollenhauer J, et al. Among authors: helmke b. Int J Cancer. 2003 Jun 10;105(2):149-57. doi: 10.1002/ijc.11072. Int J Cancer. 2003. PMID: 12673672
An integrative model on the role of DMBT1 in epithelial cancer.
Mollenhauer J, Helmke B, Müller H, Kollender G, Krebs I, Wiemann S, Holmskov U, Madsen J, Otto HF, Poustka A. Mollenhauer J, et al. Among authors: helmke b. Cancer Detect Prev. 2002;26(4):266-74. doi: 10.1016/s0361-090x(02)00094-6. Cancer Detect Prev. 2002. PMID: 12430631
The SRCR/SID region of DMBT1 defines a complex multi-allele system representing the major basis for its variability in cancer.
Mollenhauer J, Müller H, Kollender G, Lyer S, Diedrichs L, Helmke B, Holmskov U, Ligtenberg T, Herbertz S, Krebs I, Madsen J, Bikker F, Schmitt L, Wiemann S, Scheurlen W, Otto HF, von Deimling A, Poustka A. Mollenhauer J, et al. Among authors: helmke b. Genes Chromosomes Cancer. 2002 Nov;35(3):242-55. doi: 10.1002/gcc.10115. Genes Chromosomes Cancer. 2002. PMID: 12353266
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