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5'-AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP-activated protein kinase. Studies using bacterially expressed human protein phosphatase-2C alpha and native bovine protein phosphatase-2AC.
Davies SP, Helps NR, Cohen PT, Hardie DG. Davies SP, et al. Among authors: helps nr. FEBS Lett. 1995 Dec 27;377(3):421-5. doi: 10.1016/0014-5793(95)01368-7. FEBS Lett. 1995. PMID: 8549768 Free article.
SARP, a new alternatively spliced protein phosphatase 1 and DNA interacting protein.
Browne GJ, Fardilha M, Oxenham SK, Wu W, Helps NR, da Cruz E Silva OA, Cohen PT, da Cruz E Silva EF. Browne GJ, et al. Among authors: helps nr. Biochem J. 2007 Feb 15;402(1):187-96. doi: 10.1042/BJ20060600. Biochem J. 2007. PMID: 17123353 Free PMC article.
Interaction with protein phosphatase 1 Is essential for bifocal function during the morphogenesis of the Drosophila compound eye.
Helps NR, Cohen PT, Bahri SM, Chia W, Babu K. Helps NR, et al. Mol Cell Biol. 2001 Mar;21(6):2154-64. doi: 10.1128/MCB.21.6.2154-2164.2001. Mol Cell Biol. 2001. PMID: 11238949 Free PMC article.
Cloning of the complete coding region for human protein phosphatase inhibitor 2 using the two hybrid system and expression of inhibitor 2 in E. coli.
Helps NR, Street AJ, Elledge SJ, Cohen PT. Helps NR, et al. FEBS Lett. 1994 Feb 28;340(1-2):93-8. doi: 10.1016/0014-5793(94)80179-7. FEBS Lett. 1994. PMID: 8119416
The Drosophila melanogaster homologue of the human BBC1 gene is highly expressed during embryogenesis.
Helps NR, Adams SM, Brammar WJ, Varley JM. Helps NR, et al. Gene. 1995 Sep 11;162(2):245-8. doi: 10.1016/0378-1119(95)00356-b. Gene. 1995. PMID: 7557437
Protein phosphatase 4 is an essential enzyme required for organisation of microtubules at centrosomes in Drosophila embryos.
Helps NR, Brewis ND, Lineruth K, Davis T, Kaiser K, Cohen PT. Helps NR, et al. J Cell Sci. 1998 May;111 ( Pt 10):1331-40. J Cell Sci. 1998. PMID: 9570751 Free article.
Characterisation of a novel Drosophila melanogaster testis specific PP1 inhibitor related to mammalian inhibitor-2: identification of the site of interaction with PP1.
Helps NR, Vergidou C, Gaskell T, Cohen PT. Helps NR, et al. FEBS Lett. 1998 Oct 30;438(1-2):131-6. doi: 10.1016/s0014-5793(98)01286-1. FEBS Lett. 1998. PMID: 9821974 Free article.
NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1.
Helps NR, Luo X, Barker HM, Cohen PT. Helps NR, et al. Biochem J. 2000 Jul 15;349(Pt 2):509-18. doi: 10.1042/0264-6021:3490509. Biochem J. 2000. PMID: 10880350 Free PMC article.
Drosophila melanogaster protein phosphatase inhibitor-2: identification of a site important for PP1 inhibition.
Helps NR, Cohen PT. Helps NR, et al. FEBS Lett. 1999 Dec 10;463(1-2):72-6. doi: 10.1016/s0014-5793(99)01573-2. FEBS Lett. 1999. PMID: 10601641 Free article.
Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 A resolution.
Das AK, Helps NR, Cohen PT, Barford D. Das AK, et al. Among authors: helps nr. EMBO J. 1996 Dec 16;15(24):6798-809. EMBO J. 1996. PMID: 9003755 Free PMC article.
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