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Hemagglutination Inhibition Antibody Titers as a Correlate of Protection Against Seasonal A/H3N2 Influenza Disease.
Benoit A, Beran J, Devaster JM, Esen M, Launay O, Leroux-Roels G, McElhaney JE, Oostvogels L, van Essen GA, Gaglani M, Jackson LA, Vesikari T, Legrand C, Tibaldi F, Innis BL, Dewé W. Benoit A, et al. Open Forum Infect Dis. 2015 May 14;2(2):ofv067. doi: 10.1093/ofid/ofv067. eCollection 2015 Apr. Open Forum Infect Dis. 2015. PMID: 26180823 Free PMC article.
To investigate the relationship between hemagglutinin-inhibition (HI) antibody levels to the risk of influenza disease, we conducted a correlate of protection analysis using pooled data from previously published randomized trials. ...A lo …
To investigate the relationship between hemagglutinin-inhibition (HI) antibody levels to the risk of influenza disea
Neutralizing and neuraminidase antibodies correlate with protection against influenza during a late season A/H3N2 outbreak among unvaccinated military recruits.
Weiss CD, Wang W, Lu Y, Billings M, Eick-Cost A, Couzens L, Sanchez JL, Hawksworth AW, Seguin P, Myers CA, Forshee R, Eichelberger MC, Cooper MJ. Weiss CD, et al. Clin Infect Dis. 2019 Dec 16:ciz1198. doi: 10.1093/cid/ciz1198. Online ahead of print. Clin Infect Dis. 2019. PMID: 31840159
BACKGROUND: Antibodies that inhibit hemagglutination have long been considered a correlate of protection against influenza, but these antibodies are only a subset of potentially protective antibodies. ...METHODS: We measured …
BACKGROUND: Antibodies that inhibit hemagglutination have long been considered a correlate of protection against …
Evaluation of correlates of protection against influenza A(H3N2) and A(H1N1)pdm09 infection: Applications to the hospitalized patient population.
Petrie JG, Martin ET, Truscon R, Johnson E, Cheng CK, McSpadden EJ, Malosh RE, Lauring AS, Lamerato LE, Eichelberger MC, Ferdinands JM, Monto AS. Petrie JG, et al. Vaccine. 2019 Feb 28;37(10):1284-1292. doi: 10.1016/j.vaccine.2019.01.055. Epub 2019 Feb 7. Vaccine. 2019. PMID: 30738647 Free PMC article.
Serum specimens collected at hospital admission were tested in hemagglutination-inhibition (HAI) and neuraminidase-inhibition (NAI) assays. ...In both seasons, vaccinated participants had higher HAI and NAI GMTs than unvaccinated. HAI titers aga …
Serum specimens collected at hospital admission were tested in hemagglutination-inhibition (HAI) and neuraminidase-inhibiti
Single radial haemolysis compared to haemagglutinin inhibition and microneutralization as a correlate of protection against influenza A H3N2 in children and adolescents.
Wang B, Russell ML, Brewer A, Newton J, Singh P, Ward BJ, Loeb M. Wang B, et al. Influenza Other Respir Viruses. 2017 May;11(3):283-288. doi: 10.1111/irv.12450. Epub 2017 Mar 16. Influenza Other Respir Viruses. 2017. PMID: 28218983 Free PMC article. Clinical Trial.
BACKGROUND: Serum antibodies are often used as correlates of protection for influenza. Three commonly used serological assays for detecting influenza-specific serum antibodies are single radial haemolysis (SRH), haemagglutinin inhibiti
BACKGROUND: Serum antibodies are often used as correlates of protection for influenza. Three commonly used serol …
Antibodies Against Egg- and Cell-Grown Influenza A(H3N2) Viruses in Adults Hospitalized During the 2017-2018 Influenza Season.
Levine MZ, Martin ET, Petrie JG, Lauring AS, Holiday C, Jefferson S, Fitzsimmons WJ, Johnson E, Ferdinands JM, Monto AS. Levine MZ, et al. J Infect Dis. 2019 May 24;219(12):1904-1912. doi: 10.1093/infdis/jiz049. J Infect Dis. 2019. PMID: 30721982 Free PMC article.
In unadjusted models, a 2-fold increase in titers against egg-grown influenza A/Hong Kong virus was not significantly protective (29% reduction; P = .09), but a similar increase in the cell-grown influenza A/Washington virus antibody titer
In unadjusted models, a 2-fold increase in titers against egg-grown influenza A/Hong Kong virus was not significantly prote
Immunogenicity of AS03-adjuvanted and non-adjuvanted trivalent inactivated influenza vaccines in elderly adults: A Phase 3, randomized trial and post-hoc correlate of protection analysis.
Ruiz-Palacios GM, Leroux-Roels G, Beran J, Devaster JM, Esen M, Launay O, McElhaney JE, van Essen GA, Benoit A, Claeys C, Dewé W, Durand C, Duval X, Falsey AR, Feldman G, Galtier F, Gervais P, Hwang SJ, McNeil S, Richardus JH, Trofa A, Oostvogels L; Influence65 study group. Ruiz-Palacios GM, et al. Hum Vaccin Immunother. 2016 Dec;12(12):3043-3055. doi: 10.1080/21645515.2016.1219809. Hum Vaccin Immunother. 2016. PMID: 27690762 Free PMC article. Clinical Trial.
Participants received one dose of AS03-TIV or TIV in each study year and antibody titers against the vaccine strains were assessed using hemagglutination-inhibition (HI) assay at 21 d and 180 d post-vaccination in each vaccine group in the 2008/09 (Yea …
Participants received one dose of AS03-TIV or TIV in each study year and antibody titers against the vaccine strains were asse …
Inactivated H7 Influenza Virus Vaccines Protect Mice despite Inducing Only Low Levels of Neutralizing Antibodies.
Kamal RP, Blanchfield K, Belser JA, Music N, Tzeng WP, Holiday C, Burroughs A, Sun X, Maines TR, Levine MZ, York IA. Kamal RP, et al. J Virol. 2017 Sep 27;91(20):e01202-17. doi: 10.1128/JVI.01202-17. Print 2017 Oct 15. J Virol. 2017. PMID: 28768855 Free PMC article.
This study underscores the need for development of additional correlates of protection for prepandemic vaccines.IMPORTANCE H7 avian influenza viruses present a serious risk to human health. ...For seasonal influenza viruses, protection
This study underscores the need for development of additional correlates of protection for prepandemic vaccines.IMPORTANCE H7 …
[The role of antibody functional activity in the protection of people against influenza].
Naĭkhin AN, Artem'eva SA, Vybornykh EN, Popova TL, Katorgina LG, Kim TN, Kustikova IuG, Denisov GM. Naĭkhin AN, et al. Vopr Virusol. 1991 May-Jun;36(3):194-7. Vopr Virusol. 1991. PMID: 1891874 Russian.
The IFAA were found to indicate the protection of human subjects against influenza, reflecting the state of resistance to influenza more exactly than antibody titres. ...In patients with influenza the time course of antibody
The IFAA were found to indicate the protection of human subjects against influenza, reflecting the state of resistance …
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