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356 results
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Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm.
Kumar P, Henikoff S, Ng PC. Kumar P, et al. Nat Protoc. 2009;4(7):1073-81. doi: 10.1038/nprot.2009.86. Epub 2009 Jun 25. Nat Protoc. 2009. PMID: 19561590
An nsSNP could potentially affect the function of the protein, subsequently altering the carrier's phenotype. This protocol describes the use of the 'Sorting Tolerant From Intolerant' (SIFT) algorithm in predicting whether an AAS affects protein function. ...
An nsSNP could potentially affect the function of the protein, subsequently altering the carrier's phenotype. This protocol describes …
SIFT web server: predicting effects of amino acid substitutions on proteins.
Sim NL, Kumar P, Hu J, Henikoff S, Schneider G, Ng PC. Sim NL, et al. Nucleic Acids Res. 2012 Jul;40(Web Server issue):W452-7. doi: 10.1093/nar/gks539. Epub 2012 Jun 11. Nucleic Acids Res. 2012. PMID: 22689647 Free PMC article.
We have updated SIFT's genome-wide prediction tool since our last publication in 2009, and added new features to the insertion/deletion (indel) tool. ...
We have updated SIFT's genome-wide prediction tool since our last publication in 2009, and added new features to the insertion/deleti …
SIFT: Predicting amino acid changes that affect protein function.
Ng PC, Henikoff S. Ng PC, et al. Nucleic Acids Res. 2003 Jul 1;31(13):3812-4. doi: 10.1093/nar/gkg509. Nucleic Acids Res. 2003. PMID: 12824425 Free PMC article.
Accounting for human polymorphisms predicted to affect protein function.
Ng PC, Henikoff S. Ng PC, et al. Genome Res. 2002 Mar;12(3):436-46. doi: 10.1101/gr.212802. Genome Res. 2002. PMID: 11875032 Free PMC article.
A major interest in human genetics is to determine whether a nonsynonymous single-base nucleotide polymorphism (nsSNP) in a gene affects its protein product and, consequently, impacts the carrier's health. ...Two reports have indicated that there are thousands of damaging …
A major interest in human genetics is to determine whether a nonsynonymous single-base nucleotide polymorphism (nsSNP) in a gene affects its …
Predicting the effects of amino acid substitutions on protein function.
Ng PC, Henikoff S. Ng PC, et al. Annu Rev Genomics Hum Genet. 2006;7:61-80. doi: 10.1146/annurev.genom.7.080505.115630. Annu Rev Genomics Hum Genet. 2006. PMID: 16824020 Review.
Predicting deleterious amino acid substitutions.
Ng PC, Henikoff S. Ng PC, et al. Genome Res. 2001 May;11(5):863-74. doi: 10.1101/gr.176601. Genome Res. 2001. PMID: 11337480 Free PMC article.
Unlocking the secrets of the genome.
Celniker SE, Dillon LA, Gerstein MB, Gunsalus KC, Henikoff S, Karpen GH, Kellis M, Lai EC, Lieb JD, MacAlpine DM, Micklem G, Piano F, Snyder M, Stein L, White KP, Waterston RH; modENCODE Consortium. Celniker SE, et al. Nature. 2009 Jun 18;459(7249):927-30. doi: 10.1038/459927a. Nature. 2009. PMID: 19536255 Free PMC article.
Histone H2A.Z and DNA methylation are mutually antagonistic chromatin marks.
Zilberman D, Coleman-Derr D, Ballinger T, Henikoff S. Zilberman D, et al. Nature. 2008 Nov 6;456(7218):125-9. doi: 10.1038/nature07324. Epub 2008 Sep 24. Nature. 2008. PMID: 18815594 Free PMC article.
Detection of protein similarities using nucleotide sequence databases.
Henikoff S, Wallace JC. Henikoff S, et al. Nucleic Acids Res. 1988 Jul 11;16(13):6191-204. doi: 10.1093/nar/16.13.6191. Nucleic Acids Res. 1988. PMID: 3135536 Free PMC article.
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