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131 results
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Exploiting the PI3K/AKT pathway for cancer drug discovery.
Hennessy BT, Smith DL, Ram PT, Lu Y, Mills GB. Hennessy BT, et al. Nat Rev Drug Discov. 2005 Dec;4(12):988-1004. doi: 10.1038/nrd1902. Nat Rev Drug Discov. 2005. PMID: 16341064 Review.
Identification of remodeling and spacing factor 1 (rsf-1, HBXAP) at chromosome 11q13 as a putative oncogene in ovarian cancer.
Hennessy BT, Nanjundan M, Cheng KW, Nolden L, Mills GB. Hennessy BT, et al. Eur J Hum Genet. 2006 Apr;14(4):381-3. doi: 10.1038/sj.ejhg.5201570. Eur J Hum Genet. 2006. PMID: 16418735 No abstract available.
Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells.
Tibes R, Qiu Y, Lu Y, Hennessy B, Andreeff M, Mills GB, Kornblau SM. Tibes R, et al. Mol Cancer Ther. 2006 Oct;5(10):2512-21. doi: 10.1158/1535-7163.MCT-06-0334. Mol Cancer Ther. 2006. PMID: 17041095
Point mutations of protein kinases and individualised cancer therapy.
Davies M, Hennessy B, Mills GB. Davies M, et al. Expert Opin Pharmacother. 2006 Nov;7(16):2243-61. doi: 10.1517/14656566.7.16.2243. Expert Opin Pharmacother. 2006. PMID: 17059381 Review.
The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis.
Liang J, Shao SH, Xu ZX, Hennessy B, Ding Z, Larrea M, Kondo S, Dumont DJ, Gutterman JU, Walker CL, Slingerland JM, Mills GB. Liang J, et al. Nat Cell Biol. 2007 Feb;9(2):218-24. doi: 10.1038/ncb1537. Epub 2007 Jan 21. Nat Cell Biol. 2007. PMID: 17237771
A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer.
Berns K, Horlings HM, Hennessy BT, Madiredjo M, Hijmans EM, Beelen K, Linn SC, Gonzalez-Angulo AM, Stemke-Hale K, Hauptmann M, Beijersbergen RL, Mills GB, van de Vijver MJ, Bernards R. Berns K, et al. Cancer Cell. 2007 Oct;12(4):395-402. doi: 10.1016/j.ccr.2007.08.030. Cancer Cell. 2007. PMID: 17936563 Clinical Trial.
Pharmacodynamic markers of perifosine efficacy.
Hennessy BT, Lu Y, Poradosu E, Yu Q, Yu S, Hall H, Carey MS, Ravoori M, Gonzalez-Angulo AM, Birch R, Henderson IC, Kundra V, Mills GB. Hennessy BT, et al. Clin Cancer Res. 2007 Dec 15;13(24):7421-31. doi: 10.1158/1078-0432.CCR-07-0760. Clin Cancer Res. 2007. PMID: 18094426
Ovarian cancer: linking genomics to new target discovery and molecular markers--the way ahead.
Hennessy BT, Murph M, Nanjundan M, Carey M, Auersperg N, Almeida J, Coombes KR, Liu J, Lu Y, Gray JW, Mills GB. Hennessy BT, et al. Adv Exp Med Biol. 2008;617:23-40. doi: 10.1007/978-0-387-69080-3_3. Adv Exp Med Biol. 2008. PMID: 18497028 Free PMC article. Review. No abstract available.
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