Hepler JR - Search Results

1

Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity.

Jernigan KK, Cselenyi CS, Thorne CA, Hanson AJ, Tahinci E, Hajicek N, Oldham WM, Lee LA, Hamm HE, Hepler JR, Kozasa T, Linder ME, Lee E. Jernigan KK, et al. Among authors: hepler jr. Sci Signal. 2010 May 11;3(121):ra37. doi: 10.1126/scisignal.2000647. Sci Signal. 2010. PMID: 20460648 Free PMC article.

2

RGS2/G0S8 is a selective inhibitor of Gqalpha function.

Heximer SP, Watson N, Linder ME, Blumer KJ, Hepler JR. Heximer SP, et al. Among authors: hepler jr. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14389-93. doi: 10.1073/pnas.94.26.14389. Proc Natl Acad Sci U S A. 1997. PMID: 9405622 Free PMC article.

3

G protein selectivity is a determinant of RGS2 function.

Heximer SP, Srinivasa SP, Bernstein LS, Bernard JL, Linder ME, Hepler JR, Blumer KJ. Heximer SP, et al. Among authors: hepler jr. J Biol Chem. 1999 Nov 26;274(48):34253-9. doi: 10.1074/jbc.274.48.34253. J Biol Chem. 1999. PMID: 10567399 Free article.

4

Analysis of RGS protein palmitoylation.

Bernstein LS, Linder ME, Hepler JR. Bernstein LS, et al. Among authors: hepler jr. Methods Mol Biol. 2004;237:195-204. doi: 10.1385/1-59259-430-1:195. Methods Mol Biol. 2004. PMID: 14501051 Review.

5

RGS4 and GAIP are GTPase-activating proteins for Gq alpha and block activation of phospholipase C beta by gamma-thio-GTP-Gq alpha.

Hepler JR, Berman DM, Gilman AG, Kozasa T. Hepler JR, et al. Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):428-32. doi: 10.1073/pnas.94.2.428. Proc Natl Acad Sci U S A. 1997. PMID: 9012799 Free PMC article.

6

Purification from Sf9 cells and characterization of recombinant Gq alpha and G11 alpha. Activation of purified phospholipase C isozymes by G alpha subunits.

Hepler JR, Kozasa T, Smrcka AV, Simon MI, Rhee SG, Sternweis PC, Gilman AG. Hepler JR, et al. J Biol Chem. 1993 Jul 5;268(19):14367-75. J Biol Chem. 1993. PMID: 8314796 Free article.

7

Purification of recombinant Gq alpha, G11 alpha, and G16 alpha from Sf9 cells.

Hepler JR, Kozasa T, Gilman AG. Hepler JR, et al. Methods Enzymol. 1994;237:191-212. doi: 10.1016/s0076-6879(94)37063-x. Methods Enzymol. 1994. PMID: 7934997 No abstract available.

8

Lipid modifications of G proteins: alpha subunits are palmitoylated.

Linder ME, Middleton P, Hepler JR, Taussig R, Gilman AG, Mumby SM. Linder ME, et al. Among authors: hepler jr. Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3675-9. doi: 10.1073/pnas.90.8.3675. Proc Natl Acad Sci U S A. 1993. PMID: 8475115 Free PMC article.

9

Purification and characterization of recombinant G16 alpha from Sf9 cells: activation of purified phospholipase C isozymes by G-protein alpha subunits.

Kozasa T, Hepler JR, Smrcka AV, Simon MI, Rhee SG, Sternweis PC, Gilman AG. Kozasa T, et al. Among authors: hepler jr. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9176-80. doi: 10.1073/pnas.90.19.9176. Proc Natl Acad Sci U S A. 1993. PMID: 8415674 Free PMC article.

10

PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiology.

McCoy KL, Traynelis SF, Hepler JR. McCoy KL, et al. Among authors: hepler jr. Mol Pharmacol. 2010 Jun;77(6):1005-15. doi: 10.1124/mol.109.062018. Epub 2010 Mar 9. Mol Pharmacol. 2010. PMID: 20215560 Free PMC article.

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