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Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils.
Bieschke J, Herbst M, Wiglenda T, Friedrich RP, Boeddrich A, Schiele F, Kleckers D, Lopez del Amo JM, Grüning BA, Wang Q, Schmidt MR, Lurz R, Anwyl R, Schnoegl S, Fändrich M, Frank RF, Reif B, Günther S, Walsh DM, Wanker EE. Bieschke J, et al. Among authors: herbst m. Nat Chem Biol. 2011 Nov 20;8(1):93-101. doi: 10.1038/nchembio.719. Nat Chem Biol. 2011. PMID: 22101602
A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.
Goehler H, Lalowski M, Stelzl U, Waelter S, Stroedicke M, Worm U, Droege A, Lindenberg KS, Knoblich M, Haenig C, Herbst M, Suopanki J, Scherzinger E, Abraham C, Bauer B, Hasenbank R, Fritzsche A, Ludewig AH, Büssow K, Coleman SH, Gutekunst CA, Landwehrmeyer BG, Lehrach H, Wanker EE. Goehler H, et al. Among authors: herbst m. Mol Cell. 2004 Sep 24;15(6):853-65. doi: 10.1016/j.molcel.2004.09.016. Mol Cell. 2004. PMID: 15383276 Free article.
Primary cilia regulate mTORC1 activity and cell size through Lkb1.
Boehlke C, Kotsis F, Patel V, Braeg S, Voelker H, Bredt S, Beyer T, Janusch H, Hamann C, Gödel M, Müller K, Herbst M, Hornung M, Doerken M, Köttgen M, Nitschke R, Igarashi P, Walz G, Kuehn EW. Boehlke C, et al. Among authors: herbst m. Nat Cell Biol. 2010 Nov;12(11):1115-22. doi: 10.1038/ncb2117. Epub 2010 Oct 24. Nat Cell Biol. 2010. PMID: 20972424 Free PMC article.
421 results