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NDR kinases regulate essential cell processes from yeast to humans.
Hergovich A, Stegert MR, Schmitz D, Hemmings BA. Hergovich A, et al. Nat Rev Mol Cell Biol. 2006 Apr;7(4):253-64. doi: 10.1038/nrm1891. Nat Rev Mol Cell Biol. 2006. PMID: 16607288 Review.
Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL.
Hergovich A, Lisztwan J, Barry R, Ballschmieter P, Krek W. Hergovich A, et al. Nat Cell Biol. 2003 Jan;5(1):64-70. doi: 10.1038/ncb899. Nat Cell Biol. 2003. PMID: 12510195
Here we show that the VHL protein (pVHL) is a microtubule-associated protein that can protect microtubules from depolymerization in vivo. ...Our data identify a role for pVHL in the regulation of microtubule dynamics and potentially provide a link between thi …
Here we show that the VHL protein (pVHL) is a microtubule-associated protein that can protect microtubules from depolymerization in v …
Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein.
Stegert MR, Tamaskovic R, Bichsel SJ, Hergovich A, Hemmings BA. Stegert MR, et al. J Biol Chem. 2004 May 28;279(22):23806-12. doi: 10.1074/jbc.M402472200. Epub 2004 Mar 22. J Biol Chem. 2004. PMID: 15037617
This phosphorylation can be mimicked by replacing the hydrophobic motif of NDR2 with a PRK2-derived sequence, resulting in a constitutively active kinase. ...Further we show a predominant cytoplasmic localization of ectopically expressed NDR2....
This phosphorylation can be mimicked by replacing the hydrophobic motif of NDR2 with a PRK2-derived sequence, resulting in a c …
Human NDR kinases are rapidly activated by MOB proteins through recruitment to the plasma membrane and phosphorylation.
Hergovich A, Bichsel SJ, Hemmings BA. Hergovich A, et al. Mol Cell Biol. 2005 Sep;25(18):8259-72. doi: 10.1128/MCB.25.18.8259-8272.2005. Mol Cell Biol. 2005. PMID: 16135814 Free PMC article.
By using a chimeric molecule of hMOB, which allows inducible membrane translocation, we found that NDR phosphorylation and activation at the membrane occur a few minutes after association of hMOB with membranous structures. We provide insight into a potential …
By using a chimeric molecule of hMOB, which allows inducible membrane translocation, we found that NDR phosphorylation and activation …
Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3.
Stegert MR, Hergovich A, Tamaskovic R, Bichsel SJ, Hemmings BA. Stegert MR, et al. Mol Cell Biol. 2005 Dec;25(24):11019-29. doi: 10.1128/MCB.25.24.11019-11029.2005. Mol Cell Biol. 2005. PMID: 16314523 Free PMC article.
Here we show that MST3, a mammalian Ste20-like protein kinase, is able to phosphorylate NDR protein kinase at Thr444/Thr442. In vitro, MST3 selectively phosphorylated Thr442 of NDR2, resulting in a 10-fold stimulation of NDR activity. MOB1A (Mps one binder 1A) prote …
Here we show that MST3, a mammalian Ste20-like protein kinase, is able to phosphorylate NDR protein kinase at Thr444/Thr442. In vitro …
The human tumour suppressor LATS1 is activated by human MOB1 at the membrane.
Hergovich A, Schmitz D, Hemmings BA. Hergovich A, et al. Biochem Biophys Res Commun. 2006 Jun 23;345(1):50-8. doi: 10.1016/j.bbrc.2006.03.244. Epub 2006 Apr 25. Biochem Biophys Res Commun. 2006. PMID: 16674920
Here, we identified a highly conserved hMOB1-binding motif within LATS1's primary structure. While co-expression of LATS1 with hMOB1 did not elevate LATS1 kinase activity in mammalian cells, membrane-targeting of hMOB1 resulted in a significant increase of LATS1 act …
Here, we identified a highly conserved hMOB1-binding motif within LATS1's primary structure. While co-expression of LATS1 with hMOB1 …
Priming-dependent phosphorylation and regulation of the tumor suppressor pVHL by glycogen synthase kinase 3.
Hergovich A, Lisztwan J, Thoma CR, Wirbelauer C, Barry RE, Krek W. Hergovich A, et al. Mol Cell Biol. 2006 Aug;26(15):5784-96. doi: 10.1128/MCB.00232-06. Mol Cell Biol. 2006. PMID: 16847331 Free PMC article.
Here we report that pVHL30 is a novel substrate of glycogen synthase kinase 3 (GSK3) in vitro and in vivo. Phosphorylation of pVHL on serine 68 (S68) by GSK3 requires a priming phosphorylation event at serine 72 (S72) mediated in vitro by casein kinase I. ...Taken t …
Here we report that pVHL30 is a novel substrate of glycogen synthase kinase 3 (GSK3) in vitro and in vivo. Phosphorylation of pVHL on …
Centrosome-associated NDR kinase regulates centrosome duplication.
Hergovich A, Lamla S, Nigg EA, Hemmings BA. Hergovich A, et al. Mol Cell. 2007 Feb 23;25(4):625-34. doi: 10.1016/j.molcel.2007.01.020. Mol Cell. 2007. PMID: 17317633
Here, we report the first known function of a mammalian NDR kinase by demonstrating that human NDR directly contributes to centrosome duplication. A subpopulation of endogenous NDR localizes to centrosomes in a cell-cycle-dependent manner. Overexpression of N …
Here, we report the first known function of a mammalian NDR kinase by demonstrating that human NDR directly contributes to centrosome …
Mammalian NDR protein kinases: from regulation to a role in centrosome duplication.
Hergovich A, Cornils H, Hemmings BA. Hergovich A, et al. Biochim Biophys Acta. 2008 Jan;1784(1):3-15. doi: 10.1016/j.bbapap.2007.07.017. Epub 2007 Aug 15. Biochim Biophys Acta. 2008. PMID: 17881309 Review.
The NDR (nuclear Dbf2-related) family of kinases is highly conserved from yeast to human, and has been classified as a subgroup of the AGC group of protein kinases based on the sequence of the catalytic domain. ...
The NDR (nuclear Dbf2-related) family of kinases is highly conserved from yeast to human, and has been classified as a subgroup of th …
NDR kinase is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosis.
Vichalkovski A, Gresko E, Cornils H, Hergovich A, Schmitz D, Hemmings BA. Vichalkovski A, et al. Curr Biol. 2008 Dec 9;18(23):1889-95. doi: 10.1016/j.cub.2008.10.060. Curr Biol. 2008. PMID: 19062280
Human NDR1 and 2 (NDR1/2) are serine-threonine protein kinases in a subgroup of the AGC kinase family. The mechanisms of physiological NDR1/2 activation and their function remain largely unknown. ...Fas receptor stimulation promoted direct phosphorylation and activation of …
Human NDR1 and 2 (NDR1/2) are serine-threonine protein kinases in a subgroup of the AGC kinase family. The mechanisms of physiologica …
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