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Spironolactone is an antagonist of NRG1-ERBB4 signaling and schizophrenia-relevant endophenotypes in mice.
Wehr MC, Hinrichs W, Brzózka MM, Unterbarnscheidt T, Herholt A, Wintgens JP, Papiol S, Soto-Bernardini MC, Kravchenko M, Zhang M, Nave KA, Wichert SP, Falkai P, Zhang W, Schwab MH, Rossner MJ. Wehr MC, et al. Among authors: herholt a. EMBO Mol Med. 2017 Oct;9(10):1448-1462. doi: 10.15252/emmm.201707691. EMBO Mol Med. 2017. PMID: 28743784 Free PMC article.
Multiparametric Assays for Accelerating Early Drug Discovery.
Herholt A, Galinski S, Geyer PE, Rossner MJ, Wehr MC. Herholt A, et al. Trends Pharmacol Sci. 2020 May;41(5):318-335. doi: 10.1016/j.tips.2020.02.005. Epub 2020 Mar 27. Trends Pharmacol Sci. 2020. PMID: 32223968 Review.
Massively parallel functional dissection of schizophrenia-associated noncoding genetic variants.
Rummel CK, Gagliardi M, Ahmad R, Herholt A, Jimenez-Barron L, Murek V, Weigert L, Hausruckinger A, Maidl S, Hauger B, Raabe FJ, Fürle C, Trastulla L, Turecki G, Eder M, Rossner MJ, Ziller MJ. Rummel CK, et al. Among authors: herholt a. Cell. 2023 Nov 9;186(23):5165-5182.e33. doi: 10.1016/j.cell.2023.09.015. Epub 2023 Oct 17. Cell. 2023. PMID: 37852259