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Nitazoxanide, tizoxanide and a new analogue [4-nitro-N-(5-nitro-1,3-thiazol-2-yl)benzamide; NTB] inhibit the growth of kinetoplastid parasites (Trypanosoma cruzi and Leishmania mexicana) in vitro.
Chan-Bacab MJ, Hernández-Núñez E, Navarrete-Vázquez G. Chan-Bacab MJ, et al. J Antimicrob Chemother. 2009 Jun;63(6):1292-3. doi: 10.1093/jac/dkp117. Epub 2009 Apr 4. J Antimicrob Chemother. 2009. PMID: 19346519 No abstract available.
Synthesis of benzologues of Nitazoxanide and Tizoxanide: a comparative study of their in vitro broad-spectrum antiprotozoal activity.
Navarrete-Vazquez G, Chávez-Silva F, Argotte-Ramos R, Rodríguez-Gutiérrez Mdel C, Chan-Bacab MJ, Cedillo-Rivera R, Moo-Puc R, Hernández-Nuñez E. Navarrete-Vazquez G, et al. Bioorg Med Chem Lett. 2011 May 15;21(10):3168-71. doi: 10.1016/j.bmcl.2011.02.100. Epub 2011 Feb 26. Bioorg Med Chem Lett. 2011. PMID: 21397502
Design, Synthesis and Biological Evaluation of 2-(2-Amino-5(6)-nitro-1H-benzimidazol-1-yl)-N-arylacetamides as Antiprotozoal Agents.
Hernández-Núñez E, Tlahuext H, Moo-Puc R, Moreno D, González-Díaz MO, Vázquez GN. Hernández-Núñez E, et al. Molecules. 2017 Apr 4;22(4):579. doi: 10.3390/molecules22040579. Molecules. 2017. PMID: 28375176 Free PMC article.
Antiprotozoal Nitazoxanide Derivatives: Synthesis, Bioassays and QSAR Study Combined with Docking for Mechanistic Insight.
Scior T, Lozano-Aponte J, Ajmani S, Hernández-Montero E, Chávez-Silva F, Hernández-Núñez E, Moo-Puc R, Fraguela-Collar A, Navarrete-Vázquez G. Scior T, et al. Curr Comput Aided Drug Des. 2015;11(1):21-31. doi: 10.2174/1573409911666150414145937. Curr Comput Aided Drug Des. 2015. PMID: 25872791 Free PMC article.
Synthesis, Screening and in silico Simulations of Anti-Parasitic Propamidine/Benzimidazole Derivatives.
Mendez-Cuesta CA, Herrera-Rueda MA, Hidalgo-Figueroa S, Tlahuext H, Moo-Puc R, Chale-Dzul JB, Chan-Bacab M, Ortega-Morales BO, Hernandez-Nunez E, Mendez-Lucio O, Medina-Franco JL, Navarrete-Vazquez G. Mendez-Cuesta CA, et al. Med Chem. 2017;13(2):137-148. doi: 10.2174/1573406412666160811112408. Med Chem. 2017. PMID: 27527618
2-acylamino-5-nitro-1,3-thiazoles: preparation and in vitro bioevaluation against four neglected protozoan parasites.
Nava-Zuazo C, Chávez-Silva F, Moo-Puc R, Chan-Bacab MJ, Ortega-Morales BO, Moreno-Díaz H, Díaz-Coutiño D, Hernández-Núñez E, Navarrete-Vázquez G. Nava-Zuazo C, et al. Bioorg Med Chem. 2014 Mar 1;22(5):1626-33. doi: 10.1016/j.bmc.2014.01.029. Epub 2014 Jan 31. Bioorg Med Chem. 2014. PMID: 24529307
Design, Synthesis and in Combo Antidiabetic Bioevaluation of Multitarget Phenylpropanoic Acids.
Colín-Lozano B, Estrada-Soto S, Chávez-Silva F, Gutiérrez-Hernández A, Cerón-Romero L, Giacoman-Martínez A, Almanza-Pérez JC, Hernández-Núñez E, Wang Z, Xie X, Cappiello M, Balestri F, Mura U, Navarrete-Vazquez G. Colín-Lozano B, et al. Molecules. 2018 Feb 6;23(2):340. doi: 10.3390/molecules23020340. Molecules. 2018. PMID: 29415496 Free PMC article.
Synthesis, in vitro and in vivo giardicidal activity of nitrothiazole-NSAID chimeras displaying broad antiprotozoal spectrum.
Colín-Lozano B, León-Rivera I, Chan-Bacab MJ, Ortega-Morales BO, Moo-Puc R, López-Guerrero V, Hernández-Núñez E, Argüello-Garcia R, Scior T, Barbosa-Cabrera E, Navarrete-Vázquez G. Colín-Lozano B, et al. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3490-3494. doi: 10.1016/j.bmcl.2017.05.071. Epub 2017 May 24. Bioorg Med Chem Lett. 2017. PMID: 28645659
Synthesis of syn-gamma-amino-beta-hydroxyphosphonates by reduction of beta-ketophosphonates derived from L-proline and L-serine.
Ordóñez M, Lagunas-Rivera S, Hernández-Núñez E, Labastida-Galván V. Ordóñez M, et al. Molecules. 2010 Mar 4;15(3):1291-301. doi: 10.3390/molecules15031291. Molecules. 2010. PMID: 20335981 Free PMC article.
Synthesis and in vitro trichomonicidal, giardicidal and amebicidal activity of N-acetamide(sulfonamide)-2-methyl-4-nitro-1H-imidazoles.
Hernández-Núñez E, Tlahuext H, Moo-Puc R, Torres-Gómez H, Reyes-Martínez R, Cedillo-Rivera R, Nava-Zuazo C, Navarrete-Vazquez G. Hernández-Núñez E, et al. Eur J Med Chem. 2009 Jul;44(7):2975-84. doi: 10.1016/j.ejmech.2009.01.005. Epub 2009 Jan 19. Eur J Med Chem. 2009. PMID: 19208443
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