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Synthesis and biological activity of analogues of the antimicrotubule agent N,beta,beta-trimethyl-L-phenylalanyl-N(1)-[(1S,2E)-3-carboxy-1-isopropylbut-2-enyl]- N(1),3-dimethyl-L-valinamide (HTI-286).
Zask A, Birnberg G, Cheung K, Kaplan J, Niu C, Norton E, Suayan R, Yamashita A, Cole D, Tang Z, Krishnamurthy G, Williamson R, Khafizova G, Musto S, Hernandez R, Annable T, Yang X, Discafani C, Beyer C, Greenberger LM, Loganzo F, Ayral-Kaloustian S. Zask A, et al. Among authors: hernandez r. J Med Chem. 2004 Sep 9;47(19):4774-86. doi: 10.1021/jm040056u. J Med Chem. 2004. PMID: 15341492
HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.
Loganzo F, Discafani CM, Annable T, Beyer C, Musto S, Hari M, Tan X, Hardy C, Hernandez R, Baxter M, Singanallore T, Khafizova G, Poruchynsky MS, Fojo T, Nieman JA, Ayral-Kaloustian S, Zask A, Andersen RJ, Greenberger LM. Loganzo F, et al. Among authors: hernandez r. Cancer Res. 2003 Apr 15;63(8):1838-45. Cancer Res. 2003. PMID: 12702571
The interaction of PKN3 with RhoC promotes malignant growth.
Unsal-Kacmaz K, Ragunathan S, Rosfjord E, Dann S, Upeslacis E, Grillo M, Hernandez R, Mack F, Klippel A. Unsal-Kacmaz K, et al. Among authors: hernandez r. Mol Oncol. 2012 Jun;6(3):284-98. doi: 10.1016/j.molonc.2011.12.001. Epub 2011 Dec 28. Mol Oncol. 2012. PMID: 22217540 Free PMC article.
Target Development towards First Production of High-Molar- Activity 44gSc and 47Sc by Mass Separation at CERN-MEDICIS.
Mamis E, Duchemin C, Berlin V, Bernerd C, Bovigny M, Chevallay E, Crepieux B, Gadelshin VM, Heinke R, Hernandez RM, Johnson JD, Kalniņa P, Koliatos A, Lambert L, Rossel RE, Rothe S, Thiboud J, Weber F, Wendt K, Zabolockis RJ, Pajuste E, Stora T. Mamis E, et al. Among authors: hernandez rm. Pharmaceuticals (Basel). 2024 Mar 18;17(3):390. doi: 10.3390/ph17030390. Pharmaceuticals (Basel). 2024. PMID: 38543176
2,417 results