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Pathogenesis of liver fibrosis.
Hernandez-Gea V, Friedman SL. Hernandez-Gea V, et al. Annu Rev Pathol. 2011;6:425-56. doi: 10.1146/annurev-pathol-011110-130246. Annu Rev Pathol. 2011. PMID: 21073339 Review.
Impaired endothelial autophagy promotes liver fibrosis by aggravating the oxidative stress response during acute liver injury.
Ruart M, Chavarria L, Campreciós G, Suárez-Herrera N, Montironi C, Guixé-Muntet S, Bosch J, Friedman SL, Garcia-Pagán JC, Hernández-Gea V. Ruart M, et al. J Hepatol. 2019 Mar;70(3):458-469. doi: 10.1016/j.jhep.2018.10.015. Epub 2018 Oct 25. J Hepatol. 2019. PMID: 30367898 Free PMC article.
Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy.
Hernández-Gea V, Hilscher M, Rozenfeld R, Lim MP, Nieto N, Werner S, Devi LA, Friedman SL. Hernández-Gea V, et al. J Hepatol. 2013 Jul;59(1):98-104. doi: 10.1016/j.jhep.2013.02.016. Epub 2013 Feb 26. J Hepatol. 2013. PMID: 23485523 Free PMC article.
Role of the microenvironment in the pathogenesis and treatment of hepatocellular carcinoma.
Hernandez-Gea V, Toffanin S, Friedman SL, Llovet JM. Hernandez-Gea V, et al. Gastroenterology. 2013 Mar;144(3):512-27. doi: 10.1053/j.gastro.2013.01.002. Epub 2013 Jan 9. Gastroenterology. 2013. PMID: 23313965 Free PMC article. Review.
Autophagy and mesenchymal cell fibrogenesis.
Hilscher M, Hernandez-Gea V, Friedman SL. Hilscher M, et al. Biochim Biophys Acta. 2012 Jul;1831(7):972-8. doi: 10.1016/j.bbadis.2012.11.001. Epub 2012 Nov 9. Biochim Biophys Acta. 2012. PMID: 23142802 Free PMC article.
Reduced hepatic stellate cell expression of Kruppel-like factor 6 tumor suppressor isoforms amplifies fibrosis during acute and chronic rodent liver injury.
Ghiassi-Nejad Z, Hernandez-Gea V, Woodrell C, Lang UE, Dumic K, Kwong A, Friedman SL. Ghiassi-Nejad Z, et al. Hepatology. 2013 Feb;57(2):786-96. doi: 10.1002/hep.26056. Epub 2012 Dec 6. Hepatology. 2013. PMID: 22961688 Free PMC article.
Autophagy fuels tissue fibrogenesis.
Hernández-Gea V, Friedman SL. Hernández-Gea V, et al. Autophagy. 2012 May 1;8(5):849-50. doi: 10.4161/auto.19947. Epub 2012 May 1. Autophagy. 2012. PMID: 22617442 Free PMC article.
Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues.
Hernández-Gea V, Ghiassi-Nejad Z, Rozenfeld R, Gordon R, Fiel MI, Yue Z, Czaja MJ, Friedman SL. Hernández-Gea V, et al. Gastroenterology. 2012 Apr;142(4):938-46. doi: 10.1053/j.gastro.2011.12.044. Epub 2012 Jan 10. Gastroenterology. 2012. PMID: 22240484 Free PMC article.
Genomics and proteomics in liver fibrosis and cirrhosis.
Hannivoort RA, Hernandez-Gea V, Friedman SL. Hannivoort RA, et al. Fibrogenesis Tissue Repair. 2012 Jan 3;5(1):1. doi: 10.1186/1755-1536-5-1. Fibrogenesis Tissue Repair. 2012. PMID: 22214245 Free PMC article.
Krüppel-like factor 6 is a transcriptional activator of autophagy in acute liver injury.
Sydor S, Manka P, Best J, Jafoui S, Sowa JP, Zoubek ME, Hernandez-Gea V, Cubero FJ, Kälsch J, Vetter D, Fiel MI, Hoshida Y, Bian CB, Nelson LJ, Moshage H, Faber KN, Paul A, Baba HA, Gerken G, Friedman SL, Canbay A, Bechmann LP. Sydor S, et al. Sci Rep. 2017 Aug 14;7(1):8119. doi: 10.1038/s41598-017-08680-w. Sci Rep. 2017. PMID: 28808340 Free PMC article.
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