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Pfs230 yields higher malaria transmission-blocking vaccine activity than Pfs25 in humans but not mice.
Healy SA, Anderson C, Swihart BJ, Mwakingwe A, Gabriel EE, Decederfelt H, Hobbs CV, Rausch KM, Zhu D, Muratova O, Herrera R, Scaria PV, MacDonald NJ, Lambert LE, Zaidi I, Coelho CH, Renn JP, Wu Y, Narum DL, Duffy PE. Healy SA, et al. Among authors: herrera r. J Clin Invest. 2021 Apr 1;131(7):e146221. doi: 10.1172/JCI146221. J Clin Invest. 2021. PMID: 33561016 Free PMC article. Clinical Trial.
Structural and Immunological Characterization of Recombinant 6-Cysteine Domains of the Plasmodium falciparum Sexual Stage Protein Pfs230.
MacDonald NJ, Nguyen V, Shimp R, Reiter K, Herrera R, Burkhardt M, Muratova O, Kumar K, Aebig J, Rausch K, Lambert L, Dawson N, Sattabongkot J, Ambroggio X, Duffy PE, Wu Y, Narum DL. MacDonald NJ, et al. Among authors: herrera r. J Biol Chem. 2016 Sep 16;291(38):19913-22. doi: 10.1074/jbc.M116.732305. Epub 2016 Jul 18. J Biol Chem. 2016. PMID: 27432885 Free PMC article.
Safety and Immunogenicity of Pfs25-EPA/Alhydrogel®, a Transmission Blocking Vaccine against Plasmodium falciparum: An Open Label Study in Malaria Naïve Adults.
Talaat KR, Ellis RD, Hurd J, Hentrich A, Gabriel E, Hynes NA, Rausch KM, Zhu D, Muratova O, Herrera R, Anderson C, Jones D, Aebig J, Brockley S, MacDonald NJ, Wang X, Fay MP, Healy SA, Durbin AP, Narum DL, Wu Y, Duffy PE. Talaat KR, et al. Among authors: herrera r. PLoS One. 2016 Oct 17;11(10):e0163144. doi: 10.1371/journal.pone.0163144. eCollection 2016. PLoS One. 2016. PMID: 27749907 Free PMC article. Clinical Trial.
Structure and function of a malaria transmission blocking vaccine targeting Pfs230 and Pfs230-Pfs48/45 proteins.
Singh K, Burkhardt M, Nakuchima S, Herrera R, Muratova O, Gittis AG, Kelnhofer E, Reiter K, Smelkinson M, Veltri D, Swihart BJ, Shimp R Jr, Nguyen V, Zhang B, MacDonald NJ, Duffy PE, Garboczi DN, Narum DL. Singh K, et al. Among authors: herrera r. Commun Biol. 2020 Jul 24;3(1):395. doi: 10.1038/s42003-020-01123-9. Commun Biol. 2020. PMID: 32709983 Free PMC article.
A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes.
Coelho CH, Tang WK, Burkhardt M, Galson JD, Muratova O, Salinas ND, Alves E Silva TL, Reiter K, MacDonald NJ, Nguyen V, Herrera R, Shimp R, Narum DL, Byrne-Steele M, Pan W, Hou X, Brown B, Eisenhower M, Han J, Jenkins BJ, Doritchamou JYA, Smelkinson MG, Vega-Rodríguez J, Trück J, Taylor JJ, Sagara I, Healy SA, Renn JP, Tolia NH, Duffy PE. Coelho CH, et al. Among authors: herrera r. Nat Commun. 2021 Mar 19;12(1):1750. doi: 10.1038/s41467-021-21955-1. Nat Commun. 2021. PMID: 33741942 Free PMC article.
Structure of the Plasmodium falciparum circumsporozoite protein, a leading malaria vaccine candidate.
Plassmeyer ML, Reiter K, Shimp RL Jr, Kotova S, Smith PD, Hurt DE, House B, Zou X, Zhang Y, Hickman M, Uchime O, Herrera R, Nguyen V, Glen J, Lebowitz J, Jin AJ, Miller LH, MacDonald NJ, Wu Y, Narum DL. Plassmeyer ML, et al. Among authors: herrera r. J Biol Chem. 2009 Sep 25;284(39):26951-63. doi: 10.1074/jbc.M109.013706. Epub 2009 Jul 24. J Biol Chem. 2009. PMID: 19633296 Free PMC article.
Reversible Conformational Change in the Plasmodium falciparum Circumsporozoite Protein Masks Its Adhesion Domains.
Herrera R, Anderson C, Kumar K, Molina-Cruz A, Nguyen V, Burkhardt M, Reiter K, Shimp R Jr, Howard RF, Srinivasan P, Nold MJ, Ragheb D, Shi L, DeCotiis M, Aebig J, Lambert L, Rausch KM, Muratova O, Jin A, Reed SG, Sinnis P, Barillas-Mury C, Duffy PE, MacDonald NJ, Narum DL. Herrera R, et al. Infect Immun. 2015 Oct;83(10):3771-80. doi: 10.1128/IAI.02676-14. Epub 2015 Jul 13. Infect Immun. 2015. PMID: 26169272 Free PMC article.
687 results