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The ubiquitin system.
Hershko A, Ciechanover A. Hershko A, et al. Annu Rev Biochem. 1998;67:425-79. doi: 10.1146/annurev.biochem.67.1.425. Annu Rev Biochem. 1998. PMID: 9759494 Review.
In this pathway, proteins are targeted for degradation by covalent ligation to ubiquitin, a highly conserved small protein. Ubiquitin-mediated degradation of regulatory proteins plays important roles in the control of numerous processes, including cell-cycle progression, s …
In this pathway, proteins are targeted for degradation by covalent ligation to ubiquitin, a highly conserved small protein. Ubiquitin …
From rabbit reticulocytes to clam oocytes: in search of the system that targets mitotic cyclins for degradation.
Hershko A. Hershko A. Mol Biol Cell. 2010 May 15;21(10):1645-7. doi: 10.1091/mbc.e09-07-0583. Epub 2010 Mar 24. Mol Biol Cell. 2010. PMID: 20335505 Free PMC article. Review.
Using a cell-free system from clam oocytes that faithfully reproduced cell cycle stage-specific degradation of cyclins, we identified in 1995 a large ubiquitin ligase complex that targets mitotic cyclins for degradation. ...
Using a cell-free system from clam oocytes that faithfully reproduced cell cycle stage-specific degradation of cyclins, we identified …
Disassembly of mitotic checkpoint complexes by the joint action of the AAA-ATPase TRIP13 and p31(comet).
Eytan E, Wang K, Miniowitz-Shemtov S, Sitry-Shevah D, Kaisari S, Yen TJ, Liu ST, Hershko A. Eytan E, et al. Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12019-24. doi: 10.1073/pnas.1412901111. Epub 2014 Aug 4. Proc Natl Acad Sci U S A. 2014. PMID: 25092294 Free PMC article.
When the checkpoint is active, a Mitotic Checkpoint Complex (MCC) assembles and inhibits the ubiquitin ligase Anaphase-Promoting Complex/Cyclosome (APC/C). ...We now show that HeLa cell extracts contain a factor that promotes ATP- and p31(comet)-dependent disassembl …
When the checkpoint is active, a Mitotic Checkpoint Complex (MCC) assembles and inhibits the ubiquitin ligase Anaphase-Promoting Comp …
Regulation of the action of early mitotic inhibitor 1 on the anaphase-promoting complex/cyclosome by cyclin-dependent kinases.
Moshe Y, Bar-On O, Ganoth D, Hershko A. Moshe Y, et al. J Biol Chem. 2011 May 13;286(19):16647-57. doi: 10.1074/jbc.M111.223339. Epub 2011 Mar 16. J Biol Chem. 2011. PMID: 21454540 Free PMC article.
During S-phase APC/C is inhibited by early mitotic inhibitor 1 (Emi1) to allow the accumulation of cyclins A and B and to prevent re-replication. Emi1 is degraded at prophase by a Plk1-dependent pathway. Recent studies in which the degradation pathway of Emi1 was di …
During S-phase APC/C is inhibited by early mitotic inhibitor 1 (Emi1) to allow the accumulation of cyclins A and B and to prevent re- …
p31comet Promotes disassembly of the mitotic checkpoint complex in an ATP-dependent process.
Teichner A, Eytan E, Sitry-Shevah D, Miniowitz-Shemtov S, Dumin E, Gromis J, Hershko A. Teichner A, et al. Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3187-92. doi: 10.1073/pnas.1100023108. Epub 2011 Feb 7. Proc Natl Acad Sci U S A. 2011. PMID: 21300909 Free PMC article.
Accurate segregation of chromosomes in mitosis is ensured by a surveillance mechanism called the mitotic (or spindle assembly) checkpoint. ...It is known that p31(comet) prevents the formation of a Mad2 dimer that it thought to be important for turning on the mitoti …
Accurate segregation of chromosomes in mitosis is ensured by a surveillance mechanism called the mitotic (or spindle assembly) checkp …
Regulation of APC/C (Cdh1) ubiquitin ligase in differentiation of human embryonic stem cells.
Bar-On O, Shapira M, Skorecki K, Hershko A, Hershko DD. Bar-On O, et al. Cell Cycle. 2010 May 15;9(10):1986-9. doi: 10.4161/cc.9.10.11727. Epub 2010 May 15. Cell Cycle. 2010. PMID: 20473026
The rise in APC/C (Cdh1) activity with differentiation appears to be due, at least in part, to a dramatic decline in the levels of its inhibitor Emi1. ...
The rise in APC/C (Cdh1) activity with differentiation appears to be due, at least in part, to a dramatic decline in the levels of it …
Two different mitotic checkpoint inhibitors of the anaphase-promoting complex/cyclosome antagonize the action of the activator Cdc20.
Eytan E, Braunstein I, Ganoth D, Teichner A, Hittle JC, Yen TJ, Hershko A. Eytan E, et al. Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9181-5. doi: 10.1073/pnas.0804069105. Epub 2008 Jun 30. Proc Natl Acad Sci U S A. 2008. PMID: 18591651 Free PMC article.
Only a part of the inhibitory activity was caused by MCC [Braunstein I, Miniowitz S, Moshe Y, Hershko A (2007) Proc Natl Acad Sci USA 104:4870-4875]. ...We have separated a previously unknown inhibitor of APC/C from MCC. This inhibitor, called mitotic …
Only a part of the inhibitory activity was caused by MCC [Braunstein I, Miniowitz S, Moshe Y, Hershko A (2007) Proc Nat …
Inhibitory factors associated with anaphase-promoting complex/cylosome in mitotic checkpoint.
Braunstein I, Miniowitz S, Moshe Y, Hershko A. Braunstein I, et al. Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):4870-5. doi: 10.1073/pnas.0700523104. Epub 2007 Mar 13. Proc Natl Acad Sci U S A. 2007. PMID: 17360335 Free PMC article.
It affects the activity of the anaphase-promoting complex/cyclosome (APC/C), a ubiquitin ligase that targets inhibitors of anaphase initiation for degradation. ...A different model suggests that a mitotic checkpoint complex (MCC) composed of BubR1, Bub3, Cdc2 …
It affects the activity of the anaphase-promoting complex/cyclosome (APC/C), a ubiquitin ligase that targets inhibitors of anaphase i …
Regulation of neddylation and deneddylation of cullin1 in SCFSkp2 ubiquitin ligase by F-box protein and substrate.
Bornstein G, Ganoth D, Hershko A. Bornstein G, et al. Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11515-20. doi: 10.1073/pnas.0603921103. Epub 2006 Jul 21. Proc Natl Acad Sci U S A. 2006. PMID: 16861300 Free PMC article.
We examined this problem for the case of SCF(Skp2), a cullin1 (Cul1)-containing ubiquitin ligase complex that contains the S phase-associated protein Skp2 as the substrate-binding F-box protein subunit. SCF(Skp2) targets for degradation the cyclin-dependent kinase (cdk) in …
We examined this problem for the case of SCF(Skp2), a cullin1 (Cul1)-containing ubiquitin ligase complex that contains the S phase-as …
Roles of the anaphase-promoting complex/cyclosome and of its activator Cdc20 in functional substrate binding.
Eytan E, Moshe Y, Braunstein I, Hershko A. Eytan E, et al. Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2081-6. doi: 10.1073/pnas.0510695103. Epub 2006 Feb 2. Proc Natl Acad Sci U S A. 2006. PMID: 16455800 Free PMC article.
The anaphase-promoting complex/cyclosome (APC/C) is a multisubunit ubiquitin-protein ligase that targets for degradation cell-cycle regulatory proteins during exit from mitosis and in the G1 phase of the cell cycle. ...Substrates of APC/C-Cdc20 contain a recognition …
The anaphase-promoting complex/cyclosome (APC/C) is a multisubunit ubiquitin-protein ligase that targets for degradation cell-cycle r …
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