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The ubiquitin system.
Hershko A, Ciechanover A. Hershko A, et al. Annu Rev Biochem. 1998;67:425-79. doi: 10.1146/annurev.biochem.67.1.425. Annu Rev Biochem. 1998. PMID: 9759494 Review.
Two different mitotic checkpoint inhibitors of the anaphase-promoting complex/cyclosome antagonize the action of the activator Cdc20.
Eytan E, Braunstein I, Ganoth D, Teichner A, Hittle JC, Yen TJ, Hershko A. Eytan E, et al. Among authors: hershko a. Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9181-5. doi: 10.1073/pnas.0804069105. Epub 2008 Jun 30. Proc Natl Acad Sci U S A. 2008. PMID: 18591651 Free PMC article.
Little is known about the biochemical mechanisms by which this system inhibits APC/C, except for the existence of a mitotic checkpoint complex (MCC) inhibitor of APC/C composed of the APC/C activator Cdc20 associated with the checkpoint proteins Mad2, BubR1, and Bub3. ...W …
Little is known about the biochemical mechanisms by which this system inhibits APC/C, except for the existence of a mitotic checkpoin …
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