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Interleukin-15 in gene therapy of cancer.
Ochoa MC, Mazzolini G, Hervas-Stubbs S, de Sanmamed MF, Berraondo P, Melero I. Ochoa MC, et al. Curr Gene Ther. 2013 Feb;13(1):15-30. doi: 10.2174/156652313804806561. Curr Gene Ther. 2013. PMID: 23157547 Review.
Recombinant adenoviral vectors turn on the type I interferon system without inhibition of transgene expression and viral replication.
Huarte E, Larrea E, Hernández-Alcoceba R, Alfaro C, Murillo O, Arina A, Tirapu I, Azpilicueta A, Hervás-Stubbs S, Bortolanza S, Pérez-Gracia JL, Civeira MP, Prieto J, Riezu-Boj JI, Melero I. Huarte E, et al. Mol Ther. 2006 Jul;14(1):129-38. doi: 10.1016/j.ymthe.2006.02.015. Epub 2006 Apr 19. Mol Ther. 2006. PMID: 16627004
The combined actions of NK and T lymphocytes are necessary to reject an EGFP+ mesenchymal tumor through mechanisms dependent on NKG2D and IFN gamma.
Arina A, Murillo O, Hervás-Stubbs S, Azpilikueta A, Dubrot J, Tirapu I, Huarte E, Alfaro C, Pérez-Gracia JL, González-Aseguinolaza G, Sarobe P, Lasarte JJ, Jamieson A, Prieto J, Raulet DH, Melero I. Arina A, et al. Int J Cancer. 2007 Sep 15;121(6):1282-95. doi: 10.1002/ijc.22795. Int J Cancer. 2007. PMID: 17520674
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