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Systematic reviews of adverse effects: framework for a structured approach.
Loke YK, Price D, Herxheimer A; Cochrane Adverse Effects Methods Group. Loke YK, et al. BMC Med Res Methodol. 2007 Jul 5;7:32. doi: 10.1186/1471-2288-7-32. BMC Med Res Methodol. 2007. PMID: 17615054 Free PMC article. Review.
A systematic review that considers only the favourable outcomes of an intervention, without also assessing the adverse effects, can mislead by introducing a bias favouring the intervention. ...A detailed discussion of why, how and when to include adverse effe
A systematic review that considers only the favourable outcomes of an intervention, without also assessing the adverse effects, can m
Considering resistance in systematic reviews of antibiotic treatment.
Leibovici L, Soares-Weiser K, Paul M, Goldberg E, Herxheimer A, Garner P. Leibovici L, et al. J Antimicrob Chemother. 2003 Oct;52(4):564-71. doi: 10.1093/jac/dkg409. Epub 2003 Sep 1. J Antimicrob Chemother. 2003. PMID: 12951336 Review.
CONTEXT: Microorganisms resistant to antibiotic drugs are a threat to the health and chances of survival of patients. Systematic reviews on antibiotic drugs that ignore the topic of resistance present readers with a skewed view, emphasizing short-term efficacy or ef …
CONTEXT: Microorganisms resistant to antibiotic drugs are a threat to the health and chances of survival of patients. Systematic revi …
Quality of Cochrane reviews: assessment of sample from 1998.
Olsen O, Middleton P, Ezzo J, Gøtzsche PC, Hadhazy V, Herxheimer A, Kleijnen J, McIntosh H. Olsen O, et al. BMJ. 2001 Oct 13;323(7317):829-32. doi: 10.1136/bmj.323.7317.829. BMJ. 2001. PMID: 11597965 Free PMC article.
DESIGN: Ten methodologists affiliated with the Cochrane Collaboration independently examined, in a semistructured way, the quality of reviews first published in 1998. Each review was assessed by two people; if one of them noted any major problems, they agreed on a c …
DESIGN: Ten methodologists affiliated with the Cochrane Collaboration independently examined, in a semistructured way, the quality of …
Adverse effects of the antimalaria drug, mefloquine: due to primary liver damage with secondary thyroid involvement?
Croft AM, Herxheimer A. Croft AM, et al. BMC Public Health. 2002 Mar 25;2:6. doi: 10.1186/1471-2458-2-6. BMC Public Health. 2002. PMID: 11914150 Free PMC article.
PRESENTATION: We postulate that many of the adverse effects of mefloquine are a post-hepatic syndrome caused by primary liver damage. In some users we believe that symptomatic thyroid disturbance occurs, either independently or as a secondary consequence of the hepa …
PRESENTATION: We postulate that many of the adverse effects of mefloquine are a post-hepatic syndrome caused by primary liver damage. …
Assessing reports of therapeutic trials.
Lionel ND, Herxheimer A. Lionel ND, et al. Br Med J. 1970 Sep 12;3(5723):637-40. doi: 10.1136/bmj.3.5723.637. Br Med J. 1970. PMID: 4919020 Free PMC article. Clinical Trial.
A check list is described which helps the systematic assessment of reports of therapeutic trials, particularly the aspects that need to be considered in assessing their validity. ...Of these reports 51% were found to be acceptable and a further 16% probably acceptab
A check list is described which helps the systematic assessment of reports of therapeutic trials, particularly the aspects that need
Melatonin for preventing and treating jet lag.
Herxheimer A, Petrie KJ. Herxheimer A, et al. Cochrane Database Syst Rev. 2001;(1):CD001520. doi: 10.1002/14651858.CD001520. Cochrane Database Syst Rev. 2001. PMID: 11279722 Updated. Review.
Melatonin is a pineal hormone that plays a central part in regulating bodily rhythms and has been used as a drug to re-align them with the outside world. ...All compared melatonin with placebo; one in addition compared it with a hypnotic, zolpidem. Nin …
Melatonin is a pineal hormone that plays a central part in regulating bodily rhythms and has been used as a drug to re- …
How did such a bad report get published in the EJCP? Trial of paracetamol, ibuprofen and nimesulide in children with upper respiratory infections (B. Ulukol et al., EJCP November 1999, 55: 615-618).
Herxheimer A. Herxheimer A. Eur J Clin Pharmacol. 2000 Feb-Mar;55(11-12):881. doi: 10.1007/s002280050712. Eur J Clin Pharmacol. 2000. PMID: 10805069 No abstract available.
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