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The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein.
J Cell Biol. 2017 Mar 6;216(3):641-656. doi: 10.1083/jcb.201604025. Epub 2017 Feb 13.
J Cell Biol. 2017.
PMID: 28193700
Free PMC article.
Rapid in vivo validation of candidate drivers derived from the PTEN-mutant prostate metastasis genome.
Cho H, Herzka T, Stahlhut C, Watrud K, Robinson BD, Trotman LC.
Cho H, et al.
Methods. 2015 May;77-78:197-204. doi: 10.1016/j.ymeth.2014.12.022. Epub 2015 Jan 12.
Methods. 2015.
PMID: 25592467
Free PMC article.
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MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2.
Nowak DG, Cho H, Herzka T, Watrud K, DeMarco DV, Wang VM, Senturk S, Fellmann C, Ding D, Beinortas T, Kleinman D, Chen M, Sordella R, Wilkinson JE, Castillo-Martin M, Cordon-Cardo C, Robinson BD, Trotman LC.
Nowak DG, et al.
Cancer Discov. 2015 Jun;5(6):636-51. doi: 10.1158/2159-8290.CD-14-1113. Epub 2015 Mar 31.
Cancer Discov. 2015.
PMID: 25829425
Free PMC article.
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Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten-Null Cells.
Naguib A, Mathew G, Reczek CR, Watrud K, Ambrico A, Herzka T, Salas IC, Lee MF, El-Amine N, Zheng W, Di Francesco ME, Marszalek JR, Pappin DJ, Chandel NS, Trotman LC.
Naguib A, et al.
Cell Rep. 2018 Apr 3;23(1):58-67. doi: 10.1016/j.celrep.2018.03.032.
Cell Rep. 2018.
PMID: 29617673
Free PMC article.
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RapidCaP, a novel GEM model for metastatic prostate cancer analysis and therapy, reveals myc as a driver of Pten-mutant metastasis.
Cho H, Herzka T, Zheng W, Qi J, Wilkinson JE, Bradner JE, Robinson BD, Castillo-Martin M, Cordon-Cardo C, Trotman LC.
Cho H, et al.
Cancer Discov. 2014 Mar;4(3):318-33. doi: 10.1158/2159-8290.CD-13-0346. Epub 2014 Jan 20.
Cancer Discov. 2014.
PMID: 24444712
Free PMC article.
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p53 mutations change phosphatidylinositol acyl chain composition.
Naguib A, Bencze G, Engle DD, Chio II, Herzka T, Watrud K, Bencze S, Tuveson DA, Pappin DJ, Trotman LC.
Naguib A, et al.
Cell Rep. 2015 Jan 6;10(1):8-19. doi: 10.1016/j.celrep.2014.12.010. Epub 2014 Dec 24.
Cell Rep. 2015.
PMID: 25543136
Free PMC article.
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