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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1981 1
1983 2
1984 2
1985 3
1986 2
1987 4
1990 1
1991 2
1993 1
1994 1
1996 4
1997 11
1998 20
1999 25
2000 28
2001 45
2002 53
2003 36
2004 56
2005 64
2006 61
2007 73
2008 102
2009 109
2010 98
2011 98
2012 102
2013 109
2014 141
2015 157
2016 145
2017 217
2018 227
2019 246
2020 271
2021 280
2022 269
2023 77
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2,771 results
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Interleukin-1β signaling in osteoarthritis - chondrocytes in focus.
Jenei-Lanzl Z, Meurer A, Zaucke F. Jenei-Lanzl Z, et al. Cell Signal. 2019 Jan;53:212-223. doi: 10.1016/j.cellsig.2018.10.005. Epub 2018 Oct 9. Cell Signal. 2019. PMID: 30312659 Review.
In most cases, OA is associated with a variable degree of synovial inflammation. A variety of different cell types including chondrocytes, synovial fibroblasts, adipocytes, osteoblasts and osteoclasts as well as stem and immune cells are involved in catabolic and inflammat …
In most cases, OA is associated with a variable degree of synovial inflammation. A variety of different cell types including chondrocytes …
Aucubin Protects Chondrocytes Against IL-1β-Induced Apoptosis In Vitro And Inhibits Osteoarthritis In Mice Model.
Wang BW, Jiang Y, Yao ZL, Chen PS, Yu B, Wang SN. Wang BW, et al. Drug Des Devel Ther. 2019 Oct 9;13:3529-3538. doi: 10.2147/DDDT.S210220. eCollection 2019. Drug Des Devel Ther. 2019. PMID: 31631977 Free PMC article.
However, anti-osteoarthritis effect of aucubin in animal model and anti-apoptotic response of aucubin in OA chondrocytes remain unclear. This study aimed to determine whether aucubin could slow progression of OA in a mouse model and inhibit the IL-1beta-induced c …
However, anti-osteoarthritis effect of aucubin in animal model and anti-apoptotic response of aucubin in OA chondrocytes remain uncle …
Activating Nrf2 signalling alleviates osteoarthritis development by inhibiting inflammasome activation.
Yan Z, Qi W, Zhan J, Lin Z, Lin J, Xue X, Pan X, Zhou Y. Yan Z, et al. J Cell Mol Med. 2020 Nov;24(22):13046-13057. doi: 10.1111/jcmm.15905. Epub 2020 Sep 23. J Cell Mol Med. 2020. PMID: 32965793 Free PMC article.
In this study, we investigated the protective effect of Lico A on chondrocytes stimulated by lipopolysaccharide (LPS) and surgically induced OA models. In vitro, Lico A could reduce the expression of NLRP3, apoptosis-associated speck-like protein (ASC), Gasdermin D (GSDMD) …
In this study, we investigated the protective effect of Lico A on chondrocytes stimulated by lipopolysaccharide (LPS) and surgically …
Hes1, a new target for interleukin 1beta in chondrocytes.
Ottaviani S, Tahiri K, Frazier A, Hassaine ZN, Dumontier MF, Baschong W, Rannou F, Corvol MT, Savouret JF, Richette P. Ottaviani S, et al. Ann Rheum Dis. 2010 Aug;69(8):1488-94. doi: 10.1136/ard.2009.120816. Epub 2009 Nov 12. Ann Rheum Dis. 2010. PMID: 19914905
OBJECTIVES: To investigate the effects of interleukin 1beta (IL1beta) treatment on the Notch1/Hes1 pathway in chondrocytes in vitro. ...CONCLUSION: Hes1 is a novel IL1beta target gene in chondrocytes which influences a discrete sub …
OBJECTIVES: To investigate the effects of interleukin 1beta (IL1beta) treatment on the Notch1/Hes1 pathway in chondr …
Danshensu inhibits the IL-1β-induced inflammatory response in chondrocytes and osteoarthritis possibly via suppressing NF-κB signaling pathway.
Xu Z, Ke T, Zhang Y, Guo L, Chen F, He W. Xu Z, et al. Mol Med. 2021 Jul 20;27(1):80. doi: 10.1186/s10020-021-00329-9. Mol Med. 2021. PMID: 34284715 Free PMC article.
PURPOSE: Osteoarthritis (OA) is the most common inflammatory disease associated with pain and cartilage destruction. Interleukin (IL)-1beta is widely used to induce inflammatory response in OA models. This study aimed to explore the role of Danshensu (DSS) in IL- …
PURPOSE: Osteoarthritis (OA) is the most common inflammatory disease associated with pain and cartilage destruction. Interleukin (IL) …
Stigmasterol alleviates interleukin-1beta-induced chondrocyte injury by down-regulatingsterol regulatory element binding transcription factor 2 to regulateferroptosis.
Mo Z, Xu P, Li H. Mo Z, et al. Bioengineered. 2021 Dec;12(2):9332-9340. doi: 10.1080/21655979.2021.2000742. Bioengineered. 2021. PMID: 34806937 Free PMC article.
Stigmasterol (STM), one of the main active components of Achyranthes bidentata, has been shown to effectively inhibit proinflammatory factors and matrix degradation in chondrocytes. However, the effect of STM on interleukin (IL)-1beta-induced chondrocytes …
Stigmasterol (STM), one of the main active components of Achyranthes bidentata, has been shown to effectively inhibit proinflammatory factor …
Precise targeting of miR-141/200c cluster in chondrocytes attenuates osteoarthritis development.
Ji ML, Jiang H, Wu F, Geng R, Ya LK, Lin YC, Xu JH, Wu XT, Lu J. Ji ML, et al. Ann Rheum Dis. 2021 Mar;80(3):356-366. doi: 10.1136/annrheumdis-2020-218469. Epub 2020 Oct 27. Ann Rheum Dis. 2021. PMID: 33109602
The NPs are freely and deeply penetrant to mice and human cartilage, and unexpectedly persist in chondrocytes for at least 5 weeks. OA chondrocytes microenviroment improves endo/lysosomal escape of microRNAs (miRNAs). Therapeutically, IA injection of miR-141/200c in …
The NPs are freely and deeply penetrant to mice and human cartilage, and unexpectedly persist in chondrocytes for at least 5 weeks. O …
Platelet-rich plasma attenuates interleukin-1β-induced apoptosis and inflammation in chondrocytes through targeting hypoxia-inducible factor-2α.
Yang J, Guo A, Li Q, Wu J. Yang J, et al. Tissue Cell. 2021 Dec;73:101646. doi: 10.1016/j.tice.2021.101646. Epub 2021 Sep 8. Tissue Cell. 2021. PMID: 34536814
Platelet-rich plasma (PRP) has been applied as a popular non-operative treatment option for promoting musculoskeletal healing. Our previous work demonstrated that PRP protected chondrocytes from interleukin-1beta (IL-1beta)-induced apoptosis in vitro. …
Platelet-rich plasma (PRP) has been applied as a popular non-operative treatment option for promoting musculoskeletal healing. Our previous …
PPARγ Attenuates Interleukin-1β-Induced Cell Apoptosis by Inhibiting NOX2/ROS/p38MAPK Activation in Osteoarthritis Chondrocytes.
Ni S, Li D, Wei H, Miao KS, Zhuang C. Ni S, et al. Oxid Med Cell Longev. 2021 May 4;2021:5551338. doi: 10.1155/2021/5551338. eCollection 2021. Oxid Med Cell Longev. 2021. PMID: 34055194 Free PMC article.
The aim of this study was to elucidate the role of PPARgamma in interleukin-1beta- (IL-1beta-) induced cyclooxygenase-2 (COX-2) and prostaglandin E(2) (PGE(2)) expression through ROS generation in OA chondrocytes. METHODS: IL-1beta-induced ROS g …
The aim of this study was to elucidate the role of PPARgamma in interleukin-1beta- (IL-1beta-) induced cyclooxygenase-2 …
Paeonol alleviates interleukin-1β-induced inflammatory responses in chondrocytes during osteoarthritis.
Liu M, Zhong S, Kong R, Shao H, Wang C, Piao H, Lv W, Chu X, Zhao Y. Liu M, et al. Biomed Pharmacother. 2017 Nov;95:914-921. doi: 10.1016/j.biopha.2017.09.011. Epub 2017 Sep 10. Biomed Pharmacother. 2017. PMID: 28910961
Interleukin-1beta (IL-1beta)-induced inflammatory responses in chondrocytes play an important role in the pathogenesis of osteoarthritis (OA). Searching medicines that affect IL-1beta-mediated chondrocytes function is critical in developi …
Interleukin-1beta (IL-1beta)-induced inflammatory responses in chondrocytes play an important role in the pathog …
2,771 results