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Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis.
Hetz C, Lee AH, Gonzalez-Romero D, Thielen P, Castilla J, Soto C, Glimcher LH. Hetz C, et al. Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):757-62. doi: 10.1073/pnas.0711094105. Epub 2008 Jan 4. Proc Natl Acad Sci U S A. 2008. PMID: 18178615 Free PMC article.
Prion pathogenesis is independent of caspase-12.
Steele AD, Hetz C, Yi CH, Jackson WS, Borkowski AW, Yuan J, Wollmann RH, Lindquist S. Steele AD, et al. Prion. 2007 Oct-Dec;1(4):243-7. doi: 10.4161/pri.1.4.5551. Epub 2007 Oct 8. Prion. 2007. PMID: 19164919 Free PMC article.
BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha.
Lisbona F, Rojas-Rivera D, Thielen P, Zamorano S, Todd D, Martinon F, Glavic A, Kress C, Lin JH, Walter P, Reed JC, Glimcher LH, Hetz C. Lisbona F, et al. Mol Cell. 2009 Mar 27;33(6):679-91. doi: 10.1016/j.molcel.2009.02.017. Mol Cell. 2009. PMID: 19328063 Free PMC article.
XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy.
Hetz C, Thielen P, Matus S, Nassif M, Court F, Kiffin R, Martinez G, Cuervo AM, Brown RH, Glimcher LH. Hetz C, et al. Genes Dev. 2009 Oct 1;23(19):2294-306. doi: 10.1101/gad.1830709. Epub 2009 Sep 17. Genes Dev. 2009. PMID: 19762508 Free PMC article.
Amyotrophic lateral sclerosis pathogenesis: a journey through the secretory pathway.
Nassif M, Matus S, Castillo K, Hetz C. Nassif M, et al. Antioxid Redox Signal. 2010 Dec 15;13(12):1955-89. doi: 10.1089/ars.2009.2991. Epub 2010 Sep 1. Antioxid Redox Signal. 2010. PMID: 20560784 Review.
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