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Targeting the unfolded protein response in disease.
Hetz C, Chevet E, Harding HP. Hetz C, et al. Nat Rev Drug Discov. 2013 Sep;12(9):703-19. doi: 10.1038/nrd3976. Nat Rev Drug Discov. 2013. PMID: 23989796 Review.
Caspase-dependent initiation of apoptosis and necrosis by the Fas receptor in lymphoid cells: onset of necrosis is associated with delayed ceramide increase.
Hetz CA, Hunn M, Rojas P, Torres V, Leyton L, Quest AF. Hetz CA, et al. J Cell Sci. 2002 Dec 1;115(Pt 23):4671-83. doi: 10.1242/jcs.00153. J Cell Sci. 2002. PMID: 12415011
Beyond apoptosis: nonapoptotic cell death in physiology and disease.
Hetz CA, Torres V, Quest AF. Hetz CA, et al. Biochem Cell Biol. 2005 Oct;83(5):579-88. doi: 10.1139/o05-065. Biochem Cell Biol. 2005. PMID: 16234846 Review.
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha.
Hetz C, Bernasconi P, Fisher J, Lee AH, Bassik MC, Antonsson B, Brandt GS, Iwakoshi NN, Schinzel A, Glimcher LH, Korsmeyer SJ. Hetz C, et al. Science. 2006 Apr 28;312(5773):572-6. doi: 10.1126/science.1123480. Science. 2006. PMID: 16645094
Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis.
Hetz C, Lee AH, Gonzalez-Romero D, Thielen P, Castilla J, Soto C, Glimcher LH. Hetz C, et al. Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):757-62. doi: 10.1073/pnas.0711094105. Epub 2008 Jan 4. Proc Natl Acad Sci U S A. 2008. PMID: 18178615 Free PMC article.
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