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Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling.
Nakao A, Afrakhte M, Morén A, Nakayama T, Christian JL, Heuchel R, Itoh S, Kawabata M, Heldin NE, Heldin CH, ten Dijke P. Nakao A, et al. Nature. 1997 Oct 9;389(6651):631-5. doi: 10.1038/39369. Nature. 1997. PMID: 9335507
Experimental orthotopic transplantation of a tissue-engineered oesophagus in rats.
Sjöqvist S, Jungebluth P, Lim ML, Haag JC, Gustafsson Y, Lemon G, Baiguera S, Burguillos MA, Del Gaudio C, Rodríguez AB, Sotnichenko A, Kublickiene K, Ullman H, Kielstein H, Damberg P, Bianco A, Heuchel R, Zhao Y, Ribatti D, Ibarra C, Joseph B, Taylor DA, Macchiarini P. Sjöqvist S, et al. Nat Commun. 2014 Apr 15;5:3562. doi: 10.1038/ncomms4562. Nat Commun. 2014. PMID: 24736316 Free PMC article. Retracted.
Cerulein-induced pancreatic fibrosis is modulated by Smad7, the major negative regulator of transforming growth factor-β signaling.
Li X, Nania S, Fejzibegovic N, Moro CF, Klopp-Schulze L, Verbeke C, Löhr JM, Heuchel RL. Li X, et al. Biochim Biophys Acta. 2016 Sep;1862(9):1839-46. doi: 10.1016/j.bbadis.2016.06.017. Epub 2016 Jun 25. Biochim Biophys Acta. 2016. PMID: 27349482
Deletion of exon I of SMAD7 in mice results in altered B cell responses.
Li R, Rosendahl A, Brodin G, Cheng AM, Ahgren A, Sundquist C, Kulkarni S, Pawson T, Heldin CH, Heuchel RL. Li R, et al. J Immunol. 2006 Jun 1;176(11):6777-84. doi: 10.4049/jimmunol.176.11.6777. J Immunol. 2006. PMID: 16709837
Platelet-derived growth factor receptor-beta constitutive activity promotes angiogenesis in vivo and in vitro.
Magnusson PU, Looman C, Ahgren A, Wu Y, Claesson-Welsh L, Heuchel RL. Magnusson PU, et al. Arterioscler Thromb Vasc Biol. 2007 Oct;27(10):2142-9. doi: 10.1161/01.ATV.0000282198.60701.94. Epub 2007 Jul 26. Arterioscler Thromb Vasc Biol. 2007. PMID: 17656670
Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3' kinase signaling.
Heuchel R, Berg A, Tallquist M, Ahlén K, Reed RK, Rubin K, Claesson-Welsh L, Heldin CH, Soriano P. Heuchel R, et al. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11410-5. doi: 10.1073/pnas.96.20.11410. Proc Natl Acad Sci U S A. 1999. PMID: 10500190 Free PMC article.
The nucleotides responsible for the direct physical contact between the chromatin insulator protein CTCF and the H19 imprinting control region manifest parent of origin-specific long-distance insulation and methylation-free domains.
Pant V, Mariano P, Kanduri C, Mattsson A, Lobanenkov V, Heuchel R, Ohlsson R. Pant V, et al. Genes Dev. 2003 Mar 1;17(5):586-90. doi: 10.1101/gad.254903. Genes Dev. 2003. PMID: 12629040 Free PMC article.
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