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HemK2 protein, encoded on human chromosome 21, methylates translation termination factor eRF1.
Figaro S, Scrima N, Buckingham RH, Heurgué-Hamard V. Figaro S, et al. FEBS Lett. 2008 Jul 9;582(16):2352-6. doi: 10.1016/j.febslet.2008.05.045. Epub 2008 Jun 6. FEBS Lett. 2008. PMID: 18539146
Function of polypeptide chain release factor RF-3 in Escherichia coli. RF-3 action in termination is predominantly at UGA-containing stop signals.
Grentzmann G, Brechemier-Baey D, Heurgué-Hamard V, Buckingham RH. Grentzmann G, et al. J Biol Chem. 1995 May 5;270(18):10595-600. doi: 10.1074/jbc.270.18.10595. J Biol Chem. 1995. PMID: 7737996
Ribosome release factor RF4 and termination factor RF3 are involved in dissociation of peptidyl-tRNA from the ribosome.
Heurgué-Hamard V, Karimi R, Mora L, MacDougall J, Leboeuf C, Grentzmann G, Ehrenberg M, Buckingham RH. Heurgué-Hamard V, et al. EMBO J. 1998 Feb 2;17(3):808-16. doi: 10.1093/emboj/17.3.808. EMBO J. 1998. PMID: 9451005 Free PMC article.
The hemK gene in Escherichia coli encodes the N(5)-glutamine methyltransferase that modifies peptide release factors.
Heurgué-Hamard V, Champ S, Engström A, Ehrenberg M, Buckingham RH. Heurgué-Hamard V, et al. EMBO J. 2002 Feb 15;21(4):769-78. doi: 10.1093/emboj/21.4.769. EMBO J. 2002. PMID: 11847124 Free PMC article.
The essential role of the invariant GGQ motif in the function and stability in vivo of bacterial release factors RF1 and RF2.
Mora L, Heurgué-Hamard V, Champ S, Ehrenberg M, Kisselev LL, Buckingham RH. Mora L, et al. Mol Microbiol. 2003 Jan;47(1):267-75. doi: 10.1046/j.1365-2958.2003.03301.x. Mol Microbiol. 2003. PMID: 12492870
The glutamine residue of the conserved GGQ motif in Saccharomyces cerevisiae release factor eRF1 is methylated by the product of the YDR140w gene.
Heurgué-Hamard V, Champ S, Mora L, Merkulova-Rainon T, Kisselev LL, Buckingham RH. Heurgué-Hamard V, et al. J Biol Chem. 2005 Jan 28;280(4):2439-45. doi: 10.1074/jbc.M407252200. Epub 2004 Oct 27. J Biol Chem. 2005. PMID: 15509572
The N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase PrmC/HemK in Chlamydia trachomatis methylates class 1 release factors.
Pannekoek Y, Heurgué-Hamard V, Langerak AA, Speijer D, Buckingham RH, van der Ende A. Pannekoek Y, et al. J Bacteriol. 2005 Jan;187(2):507-11. doi: 10.1128/JB.187.2.507-511.2005. J Bacteriol. 2005. PMID: 15629922 Free PMC article.
Molecular basis for bacterial class I release factor methylation by PrmC.
Graille M, Heurgué-Hamard V, Champ S, Mora L, Scrima N, Ulryck N, van Tilbeurgh H, Buckingham RH. Graille M, et al. Mol Cell. 2005 Dec 22;20(6):917-27. doi: 10.1016/j.molcel.2005.10.025. Mol Cell. 2005. PMID: 16364916
The zinc finger protein Ynr046w is plurifunctional and a component of the eRF1 methyltransferase in yeast.
Heurgué-Hamard V, Graille M, Scrima N, Ulryck N, Champ S, van Tilbeurgh H, Buckingham RH. Heurgué-Hamard V, et al. J Biol Chem. 2006 Nov 24;281(47):36140-8. doi: 10.1074/jbc.M608571200. Epub 2006 Sep 28. J Biol Chem. 2006. PMID: 17008308
Methylation of bacterial release factors RF1 and RF2 is required for normal translation termination in vivo.
Mora L, Heurgué-Hamard V, de Zamaroczy M, Kervestin S, Buckingham RH. Mora L, et al. J Biol Chem. 2007 Dec 7;282(49):35638-45. doi: 10.1074/jbc.M706076200. Epub 2007 Oct 10. J Biol Chem. 2007. PMID: 17932046
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