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POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells.
Belan O, Sebald M, Adamowicz M, Anand R, Vancevska A, Neves J, Grinkevich V, Hewitt G, Segura-Bayona S, Bellelli R, Robinson HMR, Higgins GS, Smith GCM, West SC, Rueda DS, Boulton SJ. Belan O, et al. Among authors: hewitt g. Mol Cell. 2022 Dec 15;82(24):4664-4680.e9. doi: 10.1016/j.molcel.2022.11.008. Epub 2022 Nov 30. Mol Cell. 2022. PMID: 36455556 Free article.
SLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance.
Panier S, Maric M, Hewitt G, Mason-Osann E, Gali H, Dai A, Labadorf A, Guervilly JH, Ruis P, Segura-Bayona S, Belan O, Marzec P, Gaillard PL, Flynn RL, Boulton SJ. Panier S, et al. Among authors: hewitt g. Mol Cell. 2019 Oct 3;76(1):27-43.e11. doi: 10.1016/j.molcel.2019.07.010. Epub 2019 Aug 22. Mol Cell. 2019. PMID: 31447390 Free PMC article.
Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD.
Hewitt G, Borel V, Segura-Bayona S, Takaki T, Ruis P, Bellelli R, Lehmann LC, Sommerova L, Vancevska A, Tomas-Loba A, Zhu K, Cooper C, Fugger K, Patel H, Goldstone R, Schneider-Luftman D, Herbert E, Stamp G, Brough R, Pettitt S, Lord CJ, West SC, Ahel I, Ahel D, Chapman JR, Deindl S, Boulton SJ. Hewitt G, et al. Mol Cell. 2021 Feb 18;81(4):767-783.e11. doi: 10.1016/j.molcel.2020.12.006. Epub 2020 Dec 16. Mol Cell. 2021. PMID: 33333017 Free PMC article.
RTEL1 Regulates G4/R-Loops to Avert Replication-Transcription Collisions.
Kotsantis P, Segura-Bayona S, Margalef P, Marzec P, Ruis P, Hewitt G, Bellelli R, Patel H, Goldstone R, Poetsch AR, Boulton SJ. Kotsantis P, et al. Among authors: hewitt g. Cell Rep. 2020 Dec 22;33(12):108546. doi: 10.1016/j.celrep.2020.108546. Cell Rep. 2020. PMID: 33357438 Free PMC article.
Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance.
Zatreanu D, Robinson HMR, Alkhatib O, Boursier M, Finch H, Geo L, Grande D, Grinkevich V, Heald RA, Langdon S, Majithiya J, McWhirter C, Martin NMB, Moore S, Neves J, Rajendra E, Ranzani M, Schaedler T, Stockley M, Wiggins K, Brough R, Sridhar S, Gulati A, Shao N, Badder LM, Novo D, Knight EG, Marlow R, Haider S, Callen E, Hewitt G, Schimmel J, Prevo R, Alli C, Ferdinand A, Bell C, Blencowe P, Bot C, Calder M, Charles M, Curry J, Ekwuru T, Ewings K, Krajewski W, MacDonald E, McCarron H, Pang L, Pedder C, Rigoreau L, Swarbrick M, Wheatley E, Willis S, Wong AC, Nussenzweig A, Tijsterman M, Tutt A, Boulton SJ, Higgins GS, Pettitt SJ, Smith GCM, Lord CJ. Zatreanu D, et al. Among authors: hewitt g. Nat Commun. 2021 Jun 17;12(1):3636. doi: 10.1038/s41467-021-23463-8. Nat Commun. 2021. PMID: 34140467 Free PMC article.
Tackling PARP inhibitor resistance.
Fugger K, Hewitt G, West SC, Boulton SJ. Fugger K, et al. Among authors: hewitt g. Trends Cancer. 2021 Dec;7(12):1102-1118. doi: 10.1016/j.trecan.2021.08.007. Epub 2021 Sep 22. Trends Cancer. 2021. PMID: 34563478 Review.
H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ.
Bayley R, Borel V, Moss RJ, Sweatman E, Ruis P, Ormrod A, Goula A, Mottram RMA, Stanage T, Hewitt G, Saponaro M, Stewart GS, Boulton SJ, Higgs MR. Bayley R, et al. Among authors: hewitt g. Mol Cell. 2022 May 19;82(10):1924-1939.e10. doi: 10.1016/j.molcel.2022.03.030. Epub 2022 Apr 18. Mol Cell. 2022. PMID: 35439434 Free PMC article.
Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1.
Lehmann LC, Hewitt G, Aibara S, Leitner A, Marklund E, Maslen SL, Maturi V, Chen Y, van der Spoel D, Skehel JM, Moustakas A, Boulton SJ, Deindl S. Lehmann LC, et al. Among authors: hewitt g. Mol Cell. 2017 Dec 7;68(5):847-859.e7. doi: 10.1016/j.molcel.2017.10.017. Mol Cell. 2017. PMID: 29220652 Free PMC article.
364 results