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Key Challenges and Opportunities Associated with the Use of In Vitro Models to Detect Human DILI: Integrated Risk Assessment and Mitigation Plans.
Atienzar FA, Blomme EA, Chen M, Hewitt P, Kenna JG, Labbe G, Moulin F, Pognan F, Roth AB, Suter-Dick L, Ukairo O, Weaver RJ, Will Y, Dambach DM. Atienzar FA, et al. Among authors: hewitt p. Biomed Res Int. 2016;2016:9737920. doi: 10.1155/2016/9737920. Epub 2016 Sep 5. Biomed Res Int. 2016. PMID: 27689095 Free PMC article. Review.
Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication.
Sison-Young RL, Mitsa D, Jenkins RE, Mottram D, Alexandre E, Richert L, Aerts H, Weaver RJ, Jones RP, Johann E, Hewitt PG, Ingelman-Sundberg M, Goldring CE, Kitteringham NR, Park BK. Sison-Young RL, et al. Among authors: hewitt pg. Toxicol Sci. 2015 Oct;147(2):412-24. doi: 10.1093/toxsci/kfv136. Epub 2015 Jul 8. Toxicol Sci. 2015. PMID: 26160117 Free PMC article.
A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity.
Sison-Young RL, Lauschke VM, Johann E, Alexandre E, Antherieu S, Aerts H, Gerets HHJ, Labbe G, Hoët D, Dorau M, Schofield CA, Lovatt CA, Holder JC, Stahl SH, Richert L, Kitteringham NR, Jones RP, Elmasry M, Weaver RJ, Hewitt PG, Ingelman-Sundberg M, Goldring CE, Park BK. Sison-Young RL, et al. Among authors: hewitt pg. Arch Toxicol. 2017 Mar;91(3):1385-1400. doi: 10.1007/s00204-016-1745-4. Epub 2016 Jun 25. Arch Toxicol. 2017. PMID: 27344343 Free PMC article.
Test systems in drug discovery for hazard identification and risk assessment of human drug-induced liver injury.
Weaver RJ, Betts C, Blomme EAG, Gerets HHJ, Gjervig Jensen K, Hewitt PG, Juhila S, Labbe G, Liguori MJ, Mesens N, Ogese MO, Persson M, Snoeys J, Stevens JL, Walker T, Park BK. Weaver RJ, et al. Expert Opin Drug Metab Toxicol. 2017 Jul;13(7):767-782. doi: 10.1080/17425255.2017.1341489. Epub 2017 Jun 28. Expert Opin Drug Metab Toxicol. 2017. PMID: 28604124 Review.
Optimizing drug discovery by Investigative Toxicology: Current and future trends.
Beilmann M, Boonen H, Czich A, Dear G, Hewitt P, Mow T, Newham P, Oinonen T, Pognan F, Roth A, Valentin JP, Van Goethem F, Weaver RJ, Birk B, Boyer S, Caloni F, Chen AE, Corvi R, Cronin MTD, Daneshian M, Ewart LC, Fitzgerald RE, Hamilton GA, Hartung T, Kangas JD, Kramer NI, Leist M, Marx U, Polak S, Rovida C, Testai E, Van der Water B, Vulto P, Steger-Hartmann T. Beilmann M, et al. Among authors: hewitt p. ALTEX. 2019;36(2):289-313. doi: 10.14573/altex.1808181. Epub 2018 Dec 20. ALTEX. 2019. PMID: 30570669 Free article.
Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models.
Weaver RJ, Blomme EA, Chadwick AE, Copple IM, Gerets HHJ, Goldring CE, Guillouzo A, Hewitt PG, Ingelman-Sundberg M, Jensen KG, Juhila S, Klingmüller U, Labbe G, Liguori MJ, Lovatt CA, Morgan P, Naisbitt DJ, Pieters RHH, Snoeys J, van de Water B, Williams DP, Park BK. Weaver RJ, et al. Among authors: hewitt pg. Nat Rev Drug Discov. 2020 Feb;19(2):131-148. doi: 10.1038/s41573-019-0048-x. Epub 2019 Nov 20. Nat Rev Drug Discov. 2020. PMID: 31748707 Free article. Review.
Human Retinal Organoids Provide a Suitable Tool for Toxicological Investigations: A Comprehensive Validation Using Drugs and Compounds Affecting the Retina.
Dorgau B, Georgiou M, Chaudhary A, Moya-Molina M, Collin J, Queen R, Hilgen G, Davey T, Hewitt P, Schmitt M, Kustermann S, Pognan F, Steel DH, Sernagor E, Armstrong L, Lako M. Dorgau B, et al. Among authors: hewitt p. Stem Cells Transl Med. 2022 Mar 17;11(2):159-177. doi: 10.1093/stcltm/szab010. Stem Cells Transl Med. 2022. PMID: 35298655 Free PMC article.
398 results