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Page 1
Antiviral Drugs Against Severe Fever With Thrombocytopenia Syndrome Virus Infection.
Takayama-Ito M, Saijo M. Takayama-Ito M, et al. Front Microbiol. 2020 Feb 11;11:150. doi: 10.3389/fmicb.2020.00150. eCollection 2020. Front Microbiol. 2020. PMID: 32117168 Free PMC article. Review.
Because the case fatality rate of SFTS is high (6-30%), development of specific and effective treatment for SFTS is required. Studies of potential antiviral drugs for SFTS-specific therapy have been conducted on existing or newly discovered agents in vitro and in vi …
Because the case fatality rate of SFTS is high (6-30%), development of specific and effective treatment for SFTS is required. Studies of pot …
Reversible and irreversible inhibitors of coronavirus Nsp15 endoribonuclease.
Chen J, Farraj RA, Limonta D, Tabatabaei Dakhili SA, Kerek EM, Bhattacharya A, Reformat FM, Mabrouk OM, Brigant B, Pfeifer TA, McDermott MT, Ussher JR, Hobman TC, Glover JNM, Hubbard BP. Chen J, et al. J Biol Chem. 2023 Nov;299(11):105341. doi: 10.1016/j.jbc.2023.105341. Epub 2023 Oct 11. J Biol Chem. 2023. PMID: 37832873 Free PMC article.
Moreover, we demonstrate that three of these inhibitors (hexachlorophene, IPA-3, and CID5675221) block severe acute respiratory syndrome coronavirus 2 replication in cells at subtoxic doses. ...
Moreover, we demonstrate that three of these inhibitors (hexachlorophene, IPA-3, and CID5675221) block severe acute respiratory syndr …
Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus.
Yuan S, Chan JF, Ye ZW, Wen L, Tsang TG, Cao J, Huang J, Chan CC, Chik KK, Choi GK, Cai JP, Yin F, Chu H, Liang M, Jin DY, Yuen KY. Yuan S, et al. Viruses. 2019 Apr 25;11(4):385. doi: 10.3390/v11040385. Viruses. 2019. PMID: 31027241 Free PMC article.
We identified five drug compounds that inhibited SFTSV replication at low micromolar concentrations, including hexachlorophene, triclosan, regorafenib, eltrombopag, and broxyquinoline. Among them, hexachlorophene was the most potent with an IC(50) of 1.3 0.3 M an …
We identified five drug compounds that inhibited SFTSV replication at low micromolar concentrations, including hexachlorophene, tricl …
A screen of the NIH Clinical Collection small molecule library identifies potential anti-coronavirus drugs.
Cao J, Forrest JC, Zhang X. Cao J, et al. Antiviral Res. 2015 Feb;114:1-10. doi: 10.1016/j.antiviral.2014.11.010. Epub 2014 Nov 28. Antiviral Res. 2015. PMID: 25451075 Free PMC article.
Additional validation studies with the top 3 inhibitors (hexachlorophene, nitazoxanide and homoharringtonine) demonstrated robust anti-coronavirus activities (a reduction of 6 to 8log10 in virus titer) with an IC50 ranging from 11nM to 1.2muM. Furthermore, homoharringtonin …
Additional validation studies with the top 3 inhibitors (hexachlorophene, nitazoxanide and homoharringtonine) demonstrated robust ant …
Generation and characterization of Japanese encephalitis virus expressing GFP reporter gene for high throughput drug screening.
Zhang ZR, Zhang HQ, Li XD, Deng CL, Wang Z, Li JQ, Li N, Zhang QY, Zhang HL, Zhang B, Ye HQ. Zhang ZR, et al. Antiviral Res. 2020 Oct;182:104884. doi: 10.1016/j.antiviral.2020.104884. Epub 2020 Aug 1. Antiviral Res. 2020. PMID: 32750466 Free PMC article.
Therefore, it is important to establish efficient antiviral screening system for the development of antiviral drugs. In this study, we constructed a full-length infectious clone of eGFP-JEV reporter virus by inserting the eGFP gene into the capsid-coding region of t …
Therefore, it is important to establish efficient antiviral screening system for the development of antiviral drugs. In this s …
Artemisinins, new miconazole potentiators resulting in increased activity against Candida albicans biofilms.
De Cremer K, Lanckacker E, Cools TL, Bax M, De Brucker K, Cos P, Cammue BP, Thevissen K. De Cremer K, et al. Antimicrob Agents Chemother. 2015 Jan;59(1):421-6. doi: 10.1128/AAC.04229-14. Epub 2014 Nov 3. Antimicrob Agents Chemother. 2015. PMID: 25367916 Free PMC article.
Synergy between the best identified potentiators and miconazole was characterized by checkerboard analyses and fractional inhibitory concentration indices. Hexachlorophene, pyrvinium pamoate, and artesunate act synergistically with miconazole in affecting C. albicans biofi …
Synergy between the best identified potentiators and miconazole was characterized by checkerboard analyses and fractional inhibitory concent …
A screen for modulators of large T antigen's ATPase activity uncovers novel inhibitors of Simian Virus 40 and BK virus replication.
Seguin SP, Ireland AW, Gupta T, Wright CM, Miyata Y, Wipf P, Pipas JM, Gestwicki JE, Brodsky JL. Seguin SP, et al. Antiviral Res. 2012 Oct;96(1):70-81. doi: 10.1016/j.antiviral.2012.07.012. Epub 2012 Aug 7. Antiviral Res. 2012. PMID: 22898086 Free PMC article.
Lead compounds were moved into a secondary assay, and ultimately two FDA approved compounds, bithionol and hexachlorophene, were identified as the most potent TAg inhibitors known to date. Both compounds inhibited Simian Virus 40 replication as assessed by plaque assay and …
Lead compounds were moved into a secondary assay, and ultimately two FDA approved compounds, bithionol and hexachlorophene, were iden …
Evaluation of metal-conjugated compounds as inhibitors of 3CL protease of SARS-CoV.
Hsu JT, Kuo CJ, Hsieh HP, Wang YC, Huang KK, Lin CP, Huang PF, Chen X, Liang PH. Hsu JT, et al. FEBS Lett. 2004 Sep 10;574(1-3):116-20. doi: 10.1016/j.febslet.2004.08.015. FEBS Lett. 2004. PMID: 15358550 Free PMC article.
Potent inhibition was achieved using the mercury-containing compounds thimerosal and phenylmercuric acetate, as well as hexachlorophene. As well, 1-10 microM of each compound inhibited viral replication in Vero E6 cell culture. Detailed mechanism studies using a fluorescen …
Potent inhibition was achieved using the mercury-containing compounds thimerosal and phenylmercuric acetate, as well as hexachlorophene …