Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Edit custom filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 6
1995 16
1996 12
1997 28
1998 32
1999 31
2000 22
2001 21
2002 18
2003 16
2004 12
2005 9
2006 9
2007 6
2008 8
2009 5
2010 8
2011 7
2012 7
2013 5
2014 7
2015 5
2016 5
2017 7
2018 7
2019 4
2020 3
2021 7
2022 2
2023 3
2024 1
2025 1
2026 1

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

311 results

Results by year

Filters applied: . Clear all
Page 1
Hexarelin alleviates apoptosis on ischemic acute kidney injury via MDM2/p53 pathway.
Guan C, Li C, Shen X, Yang C, Liu Z, Zhang N, Xu L, Zhao L, Zhou B, Man X, Luo C, Luan H, Che L, Wang Y, Xu Y. Guan C, et al. Eur J Med Res. 2023 Sep 14;28(1):344. doi: 10.1186/s40001-023-01318-w. Eur J Med Res. 2023. PMID: 37710348 Free PMC article.
Nevertheless, the impact of Hexarelin on acute kidney injury (AKI) and its underlying mechanism remains unclear. In this study, we investigated the therapeutic potential of Hexarelin in I/R-induced AKI and elucidated its molecular mechanisms. METHODS: We assessed th …
Nevertheless, the impact of Hexarelin on acute kidney injury (AKI) and its underlying mechanism remains unclear. In this study, we in …
The cardiovascular action of hexarelin.
Mao Y, Tokudome T, Kishimoto I. Mao Y, et al. J Geriatr Cardiol. 2014 Sep;11(3):253-8. doi: 10.11909/j.issn.1671-5411.2014.03.007. J Geriatr Cardiol. 2014. PMID: 25278975 Free PMC article. Review.
Furthermore, the non-GHSR CD36 had been demonstrated to be a specific cardiac receptor for hexarelin and to mediate its cardioprotective effects. When compared with ghrelin, hexarelin is chemically more stable and functionally more potent. ...In this concise review, …
Furthermore, the non-GHSR CD36 had been demonstrated to be a specific cardiac receptor for hexarelin and to mediate its cardioprotect …
Hexarelin attenuates abdominal aortic aneurysm formation by inhibiting SMC phenotype switch and inflammasome activation.
Jiang B, Wang M, Li X, Ren P, Li G, Wang Y, Wang L, Li X, Yang D, Qin L, Xin S. Jiang B, et al. Microvasc Res. 2022 Mar;140:104280. doi: 10.1016/j.mvr.2021.104280. Epub 2021 Nov 29. Microvasc Res. 2022. PMID: 34856183
Echocardiography and in situ pictures showed hexarelin decreased infrarenal aorta diameter. Histology staining showed elastin degradation was improved in hexarelin-treated group. Hexarelin rescued smooth muscle cell contractile phenotype with increased alpha- …
Echocardiography and in situ pictures showed hexarelin decreased infrarenal aorta diameter. Histology staining showed elastin degrada …
Hexarelin protects cardiac H9C2 cells from angiotensin II-induced hypertrophy via the regulation of autophagy.
Agbo E, Li MX, Wang YQ, Saahene RO, Massaro J, Tian GZ. Agbo E, et al. Pharmazie. 2019 Aug 1;74(8):485-491. doi: 10.1691/ph.2019.9324. Pharmazie. 2019. PMID: 31526442 Free article.
Hexarelin is a synthetic growth hormone-releasing peptide that exerts cardioprotective effects. ...Ang-II induced cardiomyocyte hypertrophy, oxidative stress, apoptosis and decreased cell survival, all of which were significantly suppressed by hexarelin treatment wh …
Hexarelin is a synthetic growth hormone-releasing peptide that exerts cardioprotective effects. ...Ang-II induced cardiomyocyte hyper …
Implications of ghrelin and hexarelin in diabetes and diabetes-associated heart diseases.
Mosa RM, Zhang Z, Shao R, Deng C, Chen J, Chen C. Mosa RM, et al. Endocrine. 2015 Jun;49(2):307-23. doi: 10.1007/s12020-015-0531-z. Epub 2015 Feb 4. Endocrine. 2015. PMID: 25645463 Review.
Recently, several studies have reported other beneficial functions of GHS that are independent of GH. Ghrelin and hexarelin, for examples, have been shown to exert GH-independent cardiovascular activity. Hexarelin has been reported to regulate peroxisome proliferato …
Recently, several studies have reported other beneficial functions of GHS that are independent of GH. Ghrelin and hexarelin, for exam …
Hexarelin modulates lung mechanics, inflammation, and fibrosis in acute lung injury.
Zambelli V, Rizzi L, Delvecchio P, Bresciani E, Rezoagli E, Molteni L, Meanti R, Cuttin MS, Bovo G, Coco S, Omeljaniuk RJ, Locatelli V, Bellani G, Torsello A. Zambelli V, et al. Drug Target Insights. 2021 Nov 27;15:26-33. doi: 10.33393/dti.2021.2347. eCollection 2021 Jan-Dec. Drug Target Insights. 2021. PMID: 34871336 Free PMC article.
In this article we explore the therapeutic potential of hexarelin, a synthetic hexapeptide growth hormone secretagogue (GHS), in an experimental model of ARDS. ...At day 14, hexarelin-treated mice presented with less pulmonary collagen deposition compared with vehic …
In this article we explore the therapeutic potential of hexarelin, a synthetic hexapeptide growth hormone secretagogue (GHS), in an e …
Hexarelin: a multi-receptor peptide.
Deghenghi R. Deghenghi R. J Endocrinol Invest. 2008 Jul;31(7):680. doi: 10.1007/BF03345625. J Endocrinol Invest. 2008. PMID: 18787392 No abstract available.
Hexarelin as a test of pituitary reserve in patients with pituitary disease.
Korbonits M, Kaltsas G, Perry LA, Grossman AB, Monson JP, Besser GM, Trainer PJ. Korbonits M, et al. Clin Endocrinol (Oxf). 1999 Sep;51(3):369-75. doi: 10.1046/j.1365-2265.1999.00828.x. Clin Endocrinol (Oxf). 1999. PMID: 10469018
The patients' responses during the hexarelin test were also compared to normal ranges of GH and cortisol responses established in healthy volunteers following hexarelin administration. ...Although 17 of the 19 patients had corresponding cortisol responses to hexa …
The patients' responses during the hexarelin test were also compared to normal ranges of GH and cortisol responses established in hea …
Hexarelin attenuates atherosclerosis via inhibiting LOX-1-NF-kappaB signaling pathway-mediated macrophage ox-LDL uptake in ApoE(-/-) mice.
Cheng XL, Ding F, Wang DP, Zhou L, Cao JM. Cheng XL, et al. Peptides. 2019 Nov;121:170122. doi: 10.1016/j.peptides.2019.170122. Epub 2019 Aug 3. Peptides. 2019. PMID: 31386895
Hexarelin decreased the aortic expressions of CD68 and LOX-1 which were elevated in the AS group. ...The study supports the perspective of hexarelin as an anti-AS drug....
Hexarelin decreased the aortic expressions of CD68 and LOX-1 which were elevated in the AS group. ...The study supports the perspecti …
Hexarelin protects H9c2 cardiomyocytes from doxorubicin-induced cell death.
Filigheddu N, Fubini A, Baldanzi G, Cutrupi S, Ghè C, Catapano F, Broglio F, Bosia A, Papotti M, Muccioli G, Ghigo E, Deghenghi R, Graziani A. Filigheddu N, et al. Endocrine. 2001 Feb;14(1):113-9. doi: 10.1385/ENDO:14:1:113. Endocrine. 2001. PMID: 11322493
We show that (i)H9c2 cardiomyocytes show specific binding for 125I-Tyr-Ala-hexarelin, which is inhibited by peptidyl GHSs such as Tyr-Ala-hexarelin and hexarelin but not by the nonpeptidyl GHS MK-0677, (ii) hexarelin promotes survival of H9c2 cardiomyo …
We show that (i)H9c2 cardiomyocytes show specific binding for 125I-Tyr-Ala-hexarelin, which is inhibited by peptidyl GHSs such as Tyr …
311 results